Shu K H, Lu Y S, Chen C H, Chen D C, Lee S H, Lian J D
Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan, R.O.C.
J Formos Med Assoc. 1993 Nov;92(11):1017-20.
The pivotal role of zinc in the immune response has been well demonstrated in animals with normal renal function; however, there are fewer studies in uremic patients. Twenty uremic patients on regular hemodialysis (HD), and 20 patients on continuous ambulatory peritoneal dialysis (CAPD) were studied for their lymphoproliferative response to concanavalin A, phytohemagglutinin and pokeweed mitogen. CAPD patients had significantly lower levels of plasma zinc (65.8 micrograms/dL vs 75.1 micrograms/dL, p < 0.05) and serum albumin (3.5 g/dL vs 4.4 g/dL, p < 0.05) than HD patients. However, the stimulation indices were similar between these two groups no matter what mitogens were used, although they were significantly lower than those for the normal control group. Regression analysis revealed that there was no correlation between zinc status and the stimulation indices. However, there was a significant correlation between serum zinc and the absolute counts in HD patients. These findings suggest that zinc does not play a consistent role in the impaired lymphoproliferative response among uremic patients receiving different modes of dialysis therapy.
锌在免疫反应中的关键作用在肾功能正常的动物中已得到充分证实；然而，针对尿毒症患者的研究较少。对20例接受常规血液透析（HD）的尿毒症患者和20例接受持续性非卧床腹膜透析（CAPD）的患者，研究了他们对刀豆球蛋白A、植物血凝素和商陆有丝分裂原的淋巴细胞增殖反应。CAPD患者的血浆锌水平（65.8微克/分升对75.1微克/分升，p<0.05）和血清白蛋白水平（3.5克/分升对4.4克/分升，p<0.05）显著低于HD患者。然而，无论使用何种有丝分裂原，这两组患者的刺激指数相似，尽管它们显著低于正常对照组。回归分析显示，锌状态与刺激指数之间无相关性。然而，HD患者的血清锌与绝对计数之间存在显著相关性。这些发现表明，在接受不同透析治疗方式的尿毒症患者中，锌在受损的淋巴细胞增殖反应中并不发挥一致的作用。
