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致癌物处理大鼠培养肝细胞中维生素E、谷胱甘肽S-转移酶和γ-谷氨酰转肽酶的活性

Vitamin E, glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured hepatocytes of rats treated with carcinogens.

作者信息

Ong F B, Wan Ngah W Z, Top A G, Khalid B A, Shamaan N A

机构信息

Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur.

出版信息

Int J Biochem. 1994 Mar;26(3):397-402. doi: 10.1016/0020-711x(94)90060-4.

DOI:10.1016/0020-711x(94)90060-4
PMID:7910569
Abstract
  1. The effects of alpha-tocopherol and gamma-tocotrienol on glutathione S-transferase (GST) and gamma-glutamyl transpeptidase (gamma-GT) activities in cultured hepatocytes prepared from rats treated with diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) were investigated. 2. Both the alpha-tocopherol and gamma-tocotrienol treated hepatocytes showed significantly higher (P < 0.05) GST activities than untreated hepatocytes prepared from the carcinogen treated rats in the first 3 days of culture. Treatment with alpha-tocopherol and gamma-tocotrienol generally resulted in a tendency to increase the GST activities above that in the untreated hepatocytes. 3. Treatment with high doses (125-250 microM) of alpha-tocopherol and low doses (12.5-25 microM) of gamma-tocotrienol generally resulted in a significant reduction in gamma-GT activities at 1-3 days. gamma-GT activities are reduced as the dose of alpha-tocopherol and gamma-tocotrienol are increased.
摘要
  1. 研究了α-生育酚和γ-生育三烯酚对用二乙基亚硝胺（DEN）和2-乙酰氨基芴（AAF）处理的大鼠所制备的培养肝细胞中谷胱甘肽S-转移酶（GST）和γ-谷氨酰转肽酶（γ-GT）活性的影响。2. 在培养的前3天，用α-生育酚和γ-生育三烯酚处理的肝细胞的GST活性均显著高于从未经致癌物处理的大鼠所制备的未处理肝细胞（P < 0.05）。用α-生育酚和γ-生育三烯酚处理通常会使GST活性有高于未处理肝细胞的增加趋势。3. 高剂量（125 - 250微摩尔）的α-生育酚和低剂量（12.5 - 25微摩尔）的γ-生育三烯酚处理通常会在1 - 3天时使γ-GT活性显著降低。γ-GT活性随着α-生育酚和γ-生育三烯酚剂量的增加而降低。

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