Shamaan N A, Wan Ngah W Z, Ibrahim R, Jarien Z, Top A G, Abdul Kadir K
Jabatan Biokimia dan Mikrobiologi, Universiti Pertanian Malaysia.
Biochem Pharmacol. 1993 Apr 6;45(7):1517-9. doi: 10.1016/0006-2952(93)90052-x.
The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (cu-OOH) was increased but activity assayed with H2O2 was reduced. Supplementation of the diet with tocotrienol in the AAF-treated rats reduced the increase in enzyme activities. Tocotrienol on its own had no effect on the enzyme activities.
在20周的时间里，研究了生育三烯酚对给予2-乙酰氨基芴（AAF）的大鼠体内谷胱甘肽S-转移酶（GSTs）、谷胱甘肽还原酶（GR）和谷胱甘肽过氧化物酶（GPx）活性的影响。给予AAF后，肝脏和肾脏的GST以及肝脏的GR活性显著增加。肾脏的GPx活性受到显著影响；用氢过氧化异丙苯（cu-OOH）测定的活性增加，但用H2O2测定的活性降低。在接受AAF治疗的大鼠饮食中补充生育三烯酚可降低酶活性的增加。生育三烯酚本身对酶活性没有影响。
