生育三烯酚和生育酚处理的培养大鼠肝细胞中的谷胱甘肽S-转移酶和γ-谷氨酰转肽酶活性
Glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured rat hepatocytes treated with tocotrienol and tocopherol.
作者信息
Ong F B, Wan Ngah W Z, Shamaan N A, Md Top A G, Marzuki A, Khalid A K
机构信息
Jabatan Biokimia, Fakulti Perubatan, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala, Lumpur.
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Sep;106(1):237-40. doi: 10.1016/0742-8413(93)90277-r.
PMID:7903615
Abstract
- The effect of tocotrienol and tocopherol on glutathione S-transferase (GST) and gamma-glutamyl transpeptidase (GGT) activities in cultured rat hepatocytes were investigated. 2. Tocotrienol and tocopherol significantly decreased GGT activities at 5 days in culture but tocotrienol also significantly decreased GGT activities at 1-2 days. 3. Tocotrienol and tocopherol treatment significantly decreased GST activities at 3 days compared to the control but tocotrienol also decreased GST activities at 1-3 days. 4. Tocotrienol showed a more pronounced effect at a dosage of greater than 50 microM tocotrienol at 1-3 days in culture compared to the control.
摘要
- 研究了生育三烯酚和生育酚对培养的大鼠肝细胞中谷胱甘肽S - 转移酶（GST）和γ-谷氨酰转肽酶（GGT）活性的影响。2. 生育三烯酚和生育酚在培养5天时显著降低了GGT活性，但生育三烯酚在培养1 - 2天时也显著降低了GGT活性。3. 与对照组相比，生育三烯酚和生育酚处理在3天时显著降低了GST活性，但生育三烯酚在1 - 3天时也降低了GST活性。4. 与对照组相比，在培养1 - 3天时，剂量大于50微摩尔的生育三烯酚显示出更显著的效果。
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