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相似文献

1
Dual-action cephalosporin utilizing a novel therapeutic principle.采用新型治疗原理的双效头孢菌素。
Antimicrob Agents Chemother. 1976 Aug;10(2):249-52. doi: 10.1128/AAC.10.2.249.
2
Cefuroxime: a new cephalosporin antibiotic with enhanced stability to enterobacterial beta-lactamases.头孢呋辛：一种对肠杆菌β-内酰胺酶稳定性增强的新型头孢菌素抗生素。
J Antimicrob Chemother. 1976 Dec;2(4):337-43. doi: 10.1093/jac/2.4.337.
3
In vitro activity against Escherichia coli of CGP 9000, a new oral cephalosporin.新型口服头孢菌素CGP 9000对大肠杆菌的体外活性
J Antibiot (Tokyo). 1978 Jul;31(7):697-702. doi: 10.7164/antibiotics.31.697.
4
Antibacterial activity of ceftizoxime (FK 749), a new cephalosporin, against cephalosporin-resistant bacteria, and its stability to beta-lactamase.新型头孢菌素头孢唑肟（FK 749）对耐头孢菌素细菌的抗菌活性及其对β-内酰胺酶的稳定性。
Antimicrob Agents Chemother. 1979 Nov;16(5):549-53. doi: 10.1128/AAC.16.5.549.
5
A new cephalosporin with a dual mode of action.一种具有双重作用模式的新型头孢菌素。
Antimicrob Agents Chemother. 1976 Aug;10(2):245-8. doi: 10.1128/AAC.10.2.245.
6
Mechanisms of resistance to cephalosporins in ampicillin-resistant Escherichia coli.
J Infect Dis. 1973 Oct;128:Suppl:S335-4. doi: 10.1093/infdis/128.supplement_2.s335.
7
Potent combinations of beta-lactam antibiotics using the beta-lactamase inhibition principle.运用β-内酰胺酶抑制原理的强效β-内酰胺类抗生素组合。
Chemotherapy. 1975;21(6):330-41. doi: 10.1159/000221878.
8
[Analysis of anti-microbial resistance of Escherichia coli that caused infection in urogenital system].[引起泌尿生殖系统感染的大肠埃希菌的耐药性分析]
Di Yi Jun Yi Da Xue Xue Bao. 2004 Aug;24(8):940-2, 945.
9
Occurrence of bla mediated cephalosporin resistance in Escherichia coli and their transcriptional response against cephalosporin stress: a report from India.大肠埃希菌中 bla 介导的头孢菌素耐药性的发生及其对头孢菌素应激的转录反应：来自印度的报告。
Ann Clin Microbiol Antimicrob. 2017 Mar 21;16(1):13. doi: 10.1186/s12941-017-0189-x.
10
Response of ampicillin resistant Escherichia coli to cephalosporins in an in vitro model simulating conditions of bacterial growth in the urinary bladder.在模拟膀胱细菌生长条件的体外模型中，氨苄西林耐药性大肠杆菌对头孢菌素的反应。
Br J Exp Pathol. 1975 Apr;56(2):167-71.

引用本文的文献

1
Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research.对抗抗菌药物耐药性：抗菌研究中的创新药物
Angew Chem Int Ed Engl. 2025 Mar 3;64(10):e202414325. doi: 10.1002/anie.202414325. Epub 2025 Feb 10.
2
The Odd Couple(s): An Overview of Beta-Lactam Antibiotics Bearing More Than One Pharmacophoric Group.《Odd Couple(s): 多药效团β-内酰胺类抗生素概述》
Int J Mol Sci. 2021 Jan 9;22(2):617. doi: 10.3390/ijms22020617.
3
Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating .含双药效团的吡啶硫酮头孢菌素对复制型和非复制型均有杀灭作用。
ACS Infect Dis. 2019 Aug 9;5(8):1433-1445. doi: 10.1021/acsinfecdis.9b00112. Epub 2019 Jun 11.
4
Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria.铜影响β-内酰胺酶激活的前螯合剂对耐药细菌的抗菌效果。
ACS Infect Dis. 2018 Jun 8;4(6):1019-1029. doi: 10.1021/acsinfecdis.8b00037. Epub 2018 Mar 26.
5
In vitro activities of a dual-action antibacterial agent, Ro 23-9424, and comparative agents.双效抗菌剂Ro 23-9424及对照剂的体外活性
Antimicrob Agents Chemother. 1989 Jul;33(7):1072-7. doi: 10.1128/AAC.33.7.1072.
6
Antimicrobial activity of Ro 23-9424, a novel ester-linked codrug of fleroxacin and desacetylcefotaxime.新型酯联氟罗沙星和去乙酰头孢噻肟共聚物Ro 23-9424的抗菌活性
Antimicrob Agents Chemother. 1989 Jun;33(6):944-50. doi: 10.1128/AAC.33.6.944.

本文引用的文献

1
Use and control of cephalosporins.头孢菌素的使用与控制。
J Clin Pathol. 1971 Jul;24(5):419-29. doi: 10.1136/jcp.24.5.419.
2
The comparative performance of beta-lactam antibiotics against ampicillin sensitive Escherichia coli in conditions simulating those of the infected urinary bladder.在模拟受感染膀胱环境的条件下，β-内酰胺类抗生素对氨苄西林敏感的大肠杆菌的比较性能。
Br J Exp Pathol. 1974 Jun;55(3):245-50.
3
A twelve channel bacterial growth monitoring system.一个十二通道细菌生长监测系统。
Biomed Eng. 1973 Dec;8(12):514-5 passim.
4
Comparison of the responses of Escherichia coli and proteus mirabilis to seven beta-lactam antibodies.大肠杆菌和奇异变形杆菌对七种β-内酰胺抗体反应的比较。
J Infect Dis. 1973 Aug;128(2):211-22. doi: 10.1093/infdis/128.2.211.
5
Treatment of "bacterial cystitis" in fully automatic machanical models simulating conditions of bacterial growth in the urinary bladder.在模拟膀胱细菌生长条件的全自动机械模型中治疗“细菌性膀胱炎”。
Br J Exp Pathol. 1973 Jun;54(3):283-90.
6
Antibacterial action of "broad-spectrum" penicillins, cephalosporins and other antibiotics against Gram-negative bacilli isolated from bacteremic patients.“广谱”青霉素、头孢菌素及其他抗生素对从菌血症患者中分离出的革兰氏阴性杆菌的抗菌作用。
Ann N Y Acad Sci. 1967 Sep 27;145(2):224-36. doi: 10.1111/j.1749-6632.1967.tb50221.x.
7
Activity of cefazolin against dense populations of enterobacteria.头孢唑林对大量肠道杆菌的活性。
Antimicrob Agents Chemother. 1975 Feb;7(2):191-5. doi: 10.1128/AAC.7.2.191.
8
Response of ampicillin resistant Escherichia coli to cephalosporins in an in vitro model simulating conditions of bacterial growth in the urinary bladder.在模拟膀胱细菌生长条件的体外模型中，氨苄西林耐药性大肠杆菌对头孢菌素的反应。
Br J Exp Pathol. 1975 Apr;56(2):167-71.
9
Potent combinations of beta-lactam antibiotics using the beta-lactamase inhibition principle.运用β-内酰胺酶抑制原理的强效β-内酰胺类抗生素组合。
Chemotherapy. 1975;21(6):330-41. doi: 10.1159/000221878.
10
Resistance categories of enterobacteria to beta-lactam antibiotics.肠杆菌对β-内酰胺类抗生素的耐药类别
J Infect Dis. 1975 Sep;132(3):233-40. doi: 10.1093/infdis/132.3.233.

采用新型治疗原理的双效头孢菌素。

Dual-action cephalosporin utilizing a novel therapeutic principle.

作者信息

Greenwood D, O'Grady F

出版信息

Antimicrob Agents Chemother. 1976 Aug;10(2):249-52. doi: 10.1128/AAC.10.2.249.

DOI:10.1128/AAC.10.2.249
PMID:791095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429730/
Abstract

A new cephalosporin is described that overcomes, in a novel way, the general susceptibility of this group of agents to enterobacterial beta-lactamases. The new compound carries a substituent that is released on cleavage of the beta-lactam ring and then exhibits antibacterial activity in its own right. The possible therapeutic benefits of such an antibiotic are discussed.

摘要

描述了一种新型头孢菌素，它以一种全新的方式克服了这类药物对肠杆菌β-内酰胺酶的普遍敏感性。这种新化合物带有一个在β-内酰胺环裂解时释放的取代基，然后自身展现出抗菌活性。讨论了这种抗生素可能的治疗益处。