Greenwood D, O'Grady F
Antimicrob Agents Chemother. 1976 Aug;10(2):249-52. doi: 10.1128/AAC.10.2.249.
A new cephalosporin is described that overcomes, in a novel way, the general susceptibility of this group of agents to enterobacterial beta-lactamases. The new compound carries a substituent that is released on cleavage of the beta-lactam ring and then exhibits antibacterial activity in its own right. The possible therapeutic benefits of such an antibiotic are discussed.
描述了一种新型头孢菌素,它以一种全新的方式克服了这类药物对肠杆菌β-内酰胺酶的普遍敏感性。这种新化合物带有一个在β-内酰胺环裂解时释放的取代基,然后自身展现出抗菌活性。讨论了这种抗生素可能的治疗益处。