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N- and P-type Ca2+ channels are involved in acetylcholine release at a neuroneuronal synapse: only the N-type channel is the target of neuromodulators.N型和P型钙离子通道参与神经元间突触处的乙酰胆碱释放：只有N型通道是神经调质的作用靶点。
Proc Natl Acad Sci U S A. 1994 May 24;91(11):4771-5. doi: 10.1073/pnas.91.11.4771.
2
Presynaptic mechanisms regulating Ca2+ concentration triggering acetylcholine release at an identified neuro-neuronal synapse of Aplysia.调节钙离子浓度以触发海兔特定神经-神经元突触处乙酰胆碱释放的突触前机制。
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3
Transmitter release and calcium currents at an Aplysia buccal ganglion synapse--II. Modulation by presynaptic receptors.海兔口腔神经节突触处的递质释放与钙电流——II. 突触前受体的调制
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Role of different types of Ca2+ channels and a reticulum-like Ca2+ pump in neurotransmitter release.不同类型的钙离子通道及类内质网钙离子泵在神经递质释放中的作用。
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Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison.利用漏斗网蜘蛛毒液中的毒素组分（FTX）对哺乳动物和头足类动物神经元中的钙通道进行阻断和分离。
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本文引用的文献

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Agelenopsis aperta venom and FTX, a purified toxin, inhibit acetylcholine release in Torpedo synaptosomes.
Neuroscience. 1993 Jun;54(4):1035-41. doi: 10.1016/0306-4522(93)90593-5.
2
Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons.克隆的神经元钙通道的独特药理学和动力学及其在哺乳动物中枢神经系统神经元中可能的对应物。
Neuropharmacology. 1993 Nov;32(11):1075-88. doi: 10.1016/0028-3908(93)90003-l.
3
Transmitter release and calcium currents at an Aplysia buccal ganglion synapse--II. Modulation by presynaptic receptors.海兔口腔神经节突触处的递质释放与钙电流——II. 突触前受体的调制
Neuroscience. 1993 Mar;53(2):581-93. doi: 10.1016/0306-4522(93)90223-3.
4
Transmitter release and calcium currents at an Aplysia buccal ganglion synapse--I. Characterization.海兔口腔神经节突触处的递质释放与钙电流——I. 特性描述
Neuroscience. 1993 Mar;53(2):571-80. doi: 10.1016/0306-4522(93)90222-2.
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Involvement of calcium channels in depolarization-evoked release of adenosine from spinal cord synaptosomes.
J Neurochem. 1993 Mar;60(3):886-93. doi: 10.1111/j.1471-4159.1993.tb03233.x.
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Kinetics of calcium-dependent inactivation of calcium current in voltage-clamped neurones of Aplysia californica.加州海兔电压钳制神经元中钙电流的钙依赖性失活动力学
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Pharmacological dissection of receptor-associated and voltage-sensitive ionic channels involved in catecholamine release.对参与儿茶酚胺释放的受体相关离子通道和电压敏感性离子通道的药理学剖析。
Neuroscience. 1983 Dec;10(4):1455-62. doi: 10.1016/0306-4522(83)90126-4.
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Effects of 4-aminopyridine on potassium currents in a molluscan neuron.4-氨基吡啶对软体动物神经元钾电流的影响。
J Gen Physiol. 1981 Jul;78(1):63-86. doi: 10.1085/jgp.78.1.63.
9
Presynaptic actions of curare and atropine on quantal acetylcholine release at a central synapse of Aplysia.箭毒和阿托品对海兔中枢突触处量子化乙酰胆碱释放的突触前作用。
J Physiol. 1987 Jul;388:665-80. doi: 10.1113/jphysiol.1987.sp016637.
10
Omega-conotoxin GVIA and pharmacological modulation of hippocampal noradrenaline release.ω-芋螺毒素GVIA与海马去甲肾上腺素释放的药理学调节
Eur J Pharmacol. 1988 Mar 29;148(2):261-7. doi: 10.1016/0014-2999(88)90572-9.

N型和P型钙离子通道参与神经元间突触处的乙酰胆碱释放：只有N型通道是神经调质的作用靶点。

N- and P-type Ca2+ channels are involved in acetylcholine release at a neuroneuronal synapse: only the N-type channel is the target of neuromodulators.

作者信息

Fossier P, Baux G, Tauc L

机构信息

Laboratoire de Neurobiologie Cellulaire et Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.

出版信息

Proc Natl Acad Sci U S A. 1994 May 24;91(11):4771-5. doi: 10.1073/pnas.91.11.4771.

DOI:10.1073/pnas.91.11.4771
PMID:7910963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC43870/
Abstract

Cholinergic transmission in an identified neuro-neuronal synapse of the Aplysia buccal ganglion was depressed by application of a partially purified extract of the funnel-web-spider venom (FTx) or of its synthetic analog (sFTx). This specific blocker of voltage-dependent P-type Ca2+ channels did not interfere with the effect of the N-type Ca2+ channel blocker omega-conotoxin, which could further decrease synaptic transmission after a previous application of FTx. Similar results were obtained when the reversal order of application of these two Ca2+ channel blockers was used. Both P- and N-type Ca2+ currents trigger acetylcholine release in the presynaptic neuron. The neuromodulatory effects of FMRF-amide, histamine, and buccalin on transmitter release disappeared after the blockade of the N-type Ca2+ channels but remained still effective in the presence of FTx. These results indicate that only N-type Ca2+ channels appear to be sensitive to the neuromodulators we have identified.

摘要

应用漏斗网蜘蛛毒液（FTx）的部分纯化提取物或其合成类似物（sFTx）可抑制海兔颊神经节中一个已确定的神经-神经元突触的胆碱能传递。这种电压依赖性P型Ca2+通道的特异性阻滞剂并不干扰N型Ca2+通道阻滞剂ω-芋螺毒素的作用，在先前应用FTx后，ω-芋螺毒素可进一步降低突触传递。当使用这两种Ca2+通道阻滞剂的应用顺序颠倒时，也获得了类似的结果。P型和N型Ca2+电流均触发突触前神经元中乙酰胆碱的释放。在阻断N型Ca2+通道后，FMRF酰胺、组胺和颊肽对递质释放的神经调节作用消失，但在存在FTx的情况下仍保持有效。这些结果表明，似乎只有N型Ca2+通道对我们已鉴定出的神经调节剂敏感。