妊娠期合并肺结核的围产期结局

Perinatal outcome in pregnancies complicated by pulmonary tuberculosis.

作者信息

Jana N, Vasishta K, Jindal S K, Khunnu B, Ghosh K

机构信息

Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

Int J Gynaecol Obstet. 1994 Feb;44(2):119-24. doi: 10.1016/0020-7292(94)90064-7.

DOI:10.1016/0020-7292(94)90064-7

PMID:7911094

Abstract

OBJECTIVES

To assess the perinatal outcome of pregnancies complicated by active pulmonary tuberculosis.

METHODS

The perinatal outcome of 79 gravidas with pulmonary tuberculosis was compared with that of 316 normal gravidas of similar age, parity and socioeconomic status.

RESULTS

The mean birthweight of infants (2649 g) born to tuberculous mothers was 215 g less than that of control group (P < 0.001). Pulmonary tuberculosis was associated with an approximate 2-fold increase in prematurity (22.8% vs. 11.1%, P < 0.01), small for gestational age (20.2% vs. 7.9%, P < 0.005) and low birthweight neonates (34.2% vs. 16.5%, P < 0.001), and 6-fold increase in perinatal deaths (10.1% vs. 1.6%, P < 0.001). The adverse perinatal outcome was pronounced in cases with late diagnosis, incomplete and irregular treatment, and advanced pulmonary lesions.

CONCLUSIONS

Maternal tuberculosis is a high-risk perinatal condition. The study emphasizes the need for early diagnosis and treatment of tuberculosis, preferably before pregnancy, regular medical supervision and good perinatal care for tuberculous mothers.

摘要

目的

评估合并活动性肺结核的妊娠的围产期结局。

方法

将79例患有肺结核的孕妇的围产期结局与316例年龄、产次和社会经济地位相似的正常孕妇的围产期结局进行比较。

结果

患结核病母亲所生婴儿的平均出生体重（2649克）比对照组低215克（P<0.001）。肺结核与早产（22.8%对11.1%，P<0.01）、小于胎龄儿（20.2%对7.9%，P<0.005）和低出生体重儿（34.2%对16.5%，P<0.001）的发生率增加约2倍有关，与围产期死亡的发生率增加6倍有关（10.1%对1.6%，P<0.001）。围产期不良结局在诊断延迟、治疗不完整和不规律以及肺部病变晚期的病例中更为明显。