Yehuda S, Carasso R L, Mostofsky D I
Department of Psychology, Bar-Ilan University, Ramat Gan, Israel.
Eur J Pharmacol. 1994 Mar 11;254(1-2):193-8. doi: 10.1016/0014-2999(94)90387-5.
The anticonvulsant properties of a mixture of non-esterified alpha-linolenic acid and linoleic acid with a ratio of 1:4 (SR-3) were evaluated in four rat models of epileptic seizures: (1) i.p. injection of a single convulsant dose (50 mg/kg or 100 mg/kg) of pentylenetetrazol; (2) repeated subconvulsant doses of pentylenetetrazol; (3) cortical irritation by intraventricular administration of iron chloride (FeCl3); and (4) audiogenic seizure-prone preparation created by repeated pretreatment with p-cresol. Treatment with SR-3 (about 40 mg/kg i.p.) for a period of 3 weeks prior to challenge was found effective in each of these experimental models and caused up to a 22-fold increase in latency to major motor seizures, up to 84% reduction in the number of rats with seizures, and up to a 97% reduction in the duration of seizures. It is postulated that the anticonvulsant effects of SR-3 may be related to its stabilization of neuronal membranes. SR-3 should be evaluated further as a treatment for epilepsy.
对非酯化α-亚麻酸与亚油酸比例为1:4的混合物（SR-3）的抗惊厥特性，在四种癫痫发作大鼠模型中进行了评估：（1）腹腔注射单次惊厥剂量（50毫克/千克或100毫克/千克）的戊四氮；（2）重复给予亚惊厥剂量的戊四氮；（3）通过脑室内给予氯化铁（FeCl₃）进行皮层刺激；（4）通过对甲酚反复预处理建立的听源性惊厥易感性模型。在激发前3周，用SR-3（约40毫克/千克腹腔注射）进行治疗，发现在这些实验模型中均有效，可使严重运动性癫痫发作的潜伏期延长达22倍，癫痫发作大鼠数量减少达84%，癫痫发作持续时间缩短达97%。据推测，SR-3的抗惊厥作用可能与其对神经元膜的稳定作用有关。SR-3作为癫痫治疗药物应进一步评估。
