Pourmasoumi Makan, Vosoughi Nooshin, Derakhshandeh-Rishehri Seyedeh-Masoumeh, Assarroudi Mostafa, Heidari-Beni Motahar
Department of Community Nutrition, Food Security Research Center, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Nutrition, Faculty of Health, Bushehr University of Medical Sciences, Bushehr, Iran.
Int J Prev Med. 2018 Apr 5;9:36. doi: 10.4103/ijpvm.IJPVM_281_16. eCollection 2018.
The evidence on the association between omega-3 consumption and epileptic seizure is inconsistent. Therefore, we have conducted this systematic review to clarify the possible relationship. Original articles were searched in electronic databases (PubMed, Scopus, Google Scholar, Cochrane, and Ovid) and by reviewing the reference lists of retrieved articles. The main evaluated outcome was the epileptic seizures. We included the English language studies that reported the original data on the effect of omega-3 on epileptic human patients. We included the nine articles with 230 patients in the present systematic review. The mean ± standard deviation age of them was about 31.01 ± 14.99 years. The average of study duration was 22 ± 15.27 weeks. Omega-3 fatty acid supplements were defined as the sum of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) (1100 mg/d); as the sum of EPA, DHA, and alpha-linolenic acid (5 g/d); and as the sum of EPA alone (565 mg/d) in different studies. Among the nine studies, four studies reported a significant positive association between omega-3 fatty acids and epileptic seizures. However, power and quality of these studies are low, and we cannot consider the beneficial effect of omega-3 on seizures. In addition, five studies did not reveal any significant effect. Majority of the included studies did not show a significant association between omega-3 and epileptic seizure in epileptic patients, but further studies are necessary. It is controversial whether omega-3 fatty acids can produce positive effects on epileptic patients or not.
关于摄入ω-3与癫痫发作之间的关联，证据并不一致。因此，我们进行了这项系统评价以阐明可能的关系。通过在电子数据库（PubMed、Scopus、谷歌学术、Cochrane和Ovid）中检索原始文章，并查阅所检索文章的参考文献列表。主要评估结果是癫痫发作。我们纳入了报告ω-3对癫痫患者影响的原始数据的英文研究。在本系统评价中，我们纳入了9篇文章，共230例患者。他们的平均年龄±标准差约为31.01±14.99岁。研究持续时间的平均值为22±15.27周。在不同研究中，ω-3脂肪酸补充剂的定义分别为二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）的总和（1100毫克/天）；EPA、DHA和α-亚麻酸的总和（5克/天）；以及仅EPA的总和（565毫克/天）。在这9项研究中，4项研究报告了ω-3脂肪酸与癫痫发作之间存在显著的正相关。然而，这些研究的效能和质量较低，我们不能认为ω-3对癫痫发作有有益作用。此外，5项研究未发现任何显著影响。纳入的大多数研究未显示ω-3与癫痫患者的癫痫发作之间存在显著关联，但仍需要进一步研究。ω-3脂肪酸是否能对癫痫患者产生积极影响存在争议。
