一种改进的基于DNA的方法，用于识别有患HPA-1a（PlA1）新生儿同种免疫性血小板减少症风险的胎儿。
An improved DNA-based identification of fetuses at risk for HPA-1a (PlA1) neonatal alloimmune thrombocytopenia.
作者信息
Clemenceau S, Perichon B, Elion J, Kaplan C, Krishnamoorthy R
机构信息
Institut National de Transfusion Sanguine, Paris, France.
出版信息
Br J Haematol. 1994 Jan;86(1):198-200. doi: 10.1111/j.1365-2141.1994.tb03277.x.
Abstract
A simple and reliable procedure, based on DNA amplification and HpaII mapping, is proposed for the identification of fetuses at risk for HPA-1a (PlA1) neonatal alloimmune thrombocytopenia which could cause life-threatening haemorrhage, even in early fetal life. This typing procedure for HPA-1 alleles should help in deciding, very early, the therapeutic management of the fetuses at risk.
摘要
本文提出了一种基于DNA扩增和HpaII酶切图谱分析的简单可靠的方法，用于鉴定有HPA-1a（PlA1）新生儿同种免疫性血小板减少症风险的胎儿，这种疾病即使在胎儿早期也可能导致危及生命的出血。这种HPA-1等位基因分型方法应有助于尽早确定有风险胎儿的治疗方案。
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