Mercer D, Tang M, Marino I R, Demetris A, Fung J, Starzl T, Warty V
Department of Pathology, University of Pittsburgh Medical Center, PA 15213.
Clin Chem. 1994 Jul;40(7 Pt 1):1335-9.
We report a case of hyperphosphatasemia in a 35-year-old patient with hepatitis B who underwent an orthotopic xenogeneic liver transplant. Marked increases in total alkaline phosphatase (ALP; EC 3.1.3.1) activity began 5 days posttransplantation (six times human normal) and increased to approximately 17 times normal at day 11. Increased ALP persisted for > 40 days and steadily increased to 75 times normal in the patient's last 30 days. Gel electrophoresis detected both liver (LALP) and biliary (high-molecular-mass, BALP) isoforms. LALP measured with ion-exchange columns revealed an activity time course pattern similar to that of total ALP. Results for BALP activity also obtained with ion-exchange columns exhibited broad variability, ranging from 2 to 428 times normal.
我们报告了一例35岁接受原位异种肝移植的乙肝患者出现高磷酸酶血症的病例。移植后5天，总碱性磷酸酶（ALP；EC 3.1.3.1）活性显著升高（为人类正常水平的6倍），并在第11天增至约正常水平的17倍。ALP升高持续超过40天，并在患者最后30天稳步增至正常水平的75倍。凝胶电泳检测到肝脏（LALP）和胆汁（高分子量，BALP）同工型。用离子交换柱测量的LALP显示出与总ALP相似的活性时间进程模式。同样用离子交换柱获得的BALP活性结果显示出很大的变异性，范围从正常水平的2倍到428倍。
