Hughes R, Ingram G S, Payne J P
Br J Anaesth. 1976 Oct;48(10):969-74. doi: 10.1093/bja/48.10.969.
Intravenous doses of 0.3 mg/kg dimethyl tubocurarine were required for consistent and adequate surgical relaxation in patients during nitrous oxide anaesthesia and produced virtually complete neuromuscular paralysis (96-100%) of the tetanic and twitch responses of the adductor pollicis muscle. The duration of action of the drug was prolonged--more than 3 h was required to attain 50% recovery from full neuromuscular paralysis. At this degree of recovery neostigmine was an effective antagonist. Determination of the tetanic tension ratios showed that tetanic fade developed during onset of paralysis and remained maximal until about 25% recovery of the tetanic contractions, when it disappeared raidly as recovery progressed. These doses caused no significant changes in arterial pressure and heart rate and this absence of cardiovascular side-effects is a desirable property of dimethyl tubocurarine. However, for many surgical procedures, an agent with a similar pharmacological profile but with a shorter action is desirable.
在氧化亚氮麻醉期间，患者静脉注射0.3毫克/千克的二甲筒箭毒碱以实现持续且充分的手术松弛，该剂量可使拇收肌的强直和抽搐反应产生几乎完全的神经肌肉麻痹（96%-100%）。药物的作用持续时间延长——从完全神经肌肉麻痹恢复到50%需要超过3小时。在这种恢复程度下，新斯的明是一种有效的拮抗剂。强直张力比的测定表明，强直衰减在麻痹开始时出现，并在强直收缩恢复约25%之前一直保持最大，之后随着恢复进程迅速消失。这些剂量未引起动脉血压和心率的显著变化，二甲筒箭毒碱不存在心血管副作用这一特性是令人满意的。然而，对于许多外科手术来说，需要一种具有相似药理特性但作用时间较短的药物。
