Sugai N, Payne J P
Br J Anaesth. 1975 Oct;47(10):1061-6. doi: 10.1093/bja/47.10.1061.
The interaction of tubocurarine and suxamethonium in man was studied by the use of tetanic and single twitch contractions of the adductor pollicis muscles. Suxamethonium 0.2 mg/kg was administered at the times when the recovery of the tetanic contraction from neuromuscular blockade produced by tubocurarine 0.2 mg/kg had reached 20% and 50% of the control. At the 20% recovery point, suxamethonium improved both the tetanic and single twitch contractions; at the 50% recovery point, the single twitch response was markedly enhanced but the tetanic contraction was depressed. The findings suggest that the interaction of tubocurarine and suxamethonium is both antagonistic and synergistic. The tetanic contraction is more sensitive to the synergistic action compared with the single twitch contraction. When the interaction of these two agents is being evaluated it is important to consider the doses of the agents, the stage of curarization where the interaction took place and the method of assessing the neuromuscular blockade.
通过使用拇收肌的强直收缩和单收缩，研究了筒箭毒碱和琥珀胆碱在人体中的相互作用。在0.2mg/kg筒箭毒碱所致神经肌肉阻滞的强直收缩恢复至对照值的20%和50%时，给予0.2mg/kg琥珀胆碱。在恢复20%时，琥珀胆碱使强直收缩和单收缩均增强；在恢复50%时，单收缩反应明显增强，但强直收缩受到抑制。这些发现提示筒箭毒碱和琥珀胆碱的相互作用既有拮抗又有协同。与单收缩相比，强直收缩对协同作用更敏感。在评估这两种药物的相互作用时，考虑药物剂量、相互作用发生时的箭毒化阶段以及评估神经肌肉阻滞的方法很重要。
