Richard P, Le Floch R, Chamoux C, Pannier M, Espaze E, Richet H
Laboratoire de Bactériologie A, CHU Hôtel-Dieu, Nantes, France.
J Infect Dis. 1994 Aug;170(2):377-83. doi: 10.1093/infdis/170.2.377.
An environmental survey and a cohort study were done to analyze an outbreak of infections in a burn unit caused by a serotype O:11 and a multidrug-resistant serotype O:12 Pseudomonas aeruginosa. The P. aeruginosa O:11 outbreak was controlled by eradicating an environmental source, contaminated hydrotherapy equipment. To assess risk factors for infections caused by P. aeruginosa O:12, 15 infected burn patients were compared with 32 noninfected burn patients hospitalized during the outbreak. Patients had similar extent, severity, location, and care of burn injuries, exposure to invasive procedures, and past history of P. aeruginosa infection. Prior treatment with ceftazidime (3 g/day) was the only independent risk factor for P. aeruginosa O:12 infection. The outbreak was controlled by increasing the daily administration of ceftazidime from 3 to 6 g and by a reinforcement of isolation precautions.
开展了一项环境调查和一项队列研究，以分析由血清型O:11和多重耐药血清型O:12铜绿假单胞菌引起的烧伤病房感染暴发情况。通过根除一个环境源，即受污染的水疗设备，控制了血清型O:11铜绿假单胞菌的暴发。为评估血清型O:12铜绿假单胞菌感染的危险因素，将15例感染烧伤患者与暴发期间住院的32例未感染烧伤患者进行了比较。患者在烧伤的范围、严重程度、部位和护理、侵入性操作暴露情况以及既往铜绿假单胞菌感染史方面相似。既往使用头孢他啶（3g/天）治疗是血清型O:12铜绿假单胞菌感染的唯一独立危险因素。通过将头孢他啶的每日给药量从3g增加到6g以及加强隔离预防措施，控制了此次暴发。
