King D J
Department of Psychopharmacology, Queen's University of Belfast, Northern Ireland, United Kingdom.
Acta Psychiatr Scand Suppl. 1994;380:53-8. doi: 10.1111/j.1600-0447.1994.tb05833.x.
Reviews of the literature have failed to demonstrate any consistent effects of typical or atypical neuroleptics on psychomotor or cognitive function in schizophrenic patients. Better methods and study designs are required, and healthy volunteer studies are necessary to control for variables due to schizophrenic psychopathology. Eye movements are a sensitive, reliable and relatively pure measure of attention and arousal. Two volunteer studies of the effects of single doses of haloperidol (2,4 and 6 mg), chlorpromazine (50 mg) and remoxipride (100 and 150 mg) on saccadic and smooth pursuit eye movements are described. All drugs impaired both eye movement measures, but the doses used were not clinically equivalent. No available test is yet able to distinguish between benzodiazepines and neuroleptics.
文献综述未能证明典型或非典型抗精神病药物对精神分裂症患者的精神运动或认知功能有任何一致的影响。需要更好的方法和研究设计，并且有必要进行健康志愿者研究，以控制精神分裂症精神病理学所导致的变量。眼球运动是注意力和觉醒的一种敏感、可靠且相对纯粹的测量指标。本文描述了两项关于单剂量氟哌啶醇（2、4和6毫克）、氯丙嗪（50毫克）和瑞莫必利（100和150毫克）对扫视和平稳跟踪眼球运动影响的志愿者研究。所有药物均损害了这两种眼球运动指标，但所用剂量在临床上并不等效。目前尚无可用的测试能够区分苯二氮䓬类药物和抗精神病药物。
