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Protective effect of apoE epsilon 2 in Alzheimer's disease.

作者信息

Benjamin R, Leake A, McArthur F K, Ince P G, Candy J M, Edwardson J A, Morris C M, Bjertness E

出版信息

Lancet. 1994 Aug 13;344(8920):473. doi: 10.1016/s0140-6736(94)91804-x.

DOI:10.1016/s0140-6736(94)91804-x
PMID:7914580
Abstract
摘要

相似文献

1
Protective effect of apoE epsilon 2 in Alzheimer's disease.
Lancet. 1994 Aug 13;344(8920):473. doi: 10.1016/s0140-6736(94)91804-x.
2
The apolipoprotein E allele epsilon 4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease.载脂蛋白Eε4等位基因在路易体变异型阿尔茨海默病患者中过度表达。
Neurology. 1994 Oct;44(10):1950-1. doi: 10.1212/wnl.44.10.1950.
3
Risk and protective effects of the APOE gene towards Alzheimer's disease in the Kungsholmen project: variation by age and sex.在孔斯霍门项目中,APOE基因对阿尔茨海默病的风险及保护作用:随年龄和性别的变化
J Neurol Neurosurg Psychiatry. 2004 Jun;75(6):828-33. doi: 10.1136/jnnp.2003.021493.
4
Apolipoprotein E-epsilon 2 and Alzheimer's disease: genotype influences pathologic phenotype.载脂蛋白E-ε2与阿尔茨海默病:基因型影响病理表型。
Neurology. 1997 Feb;48(2):515-9. doi: 10.1212/wnl.48.2.515.
5
High frequency of apolipoprotein E epsilon 2 allele in hemorrhage due to cerebral amyloid angiopathy.载脂蛋白Eε2等位基因在脑淀粉样血管病所致出血中出现频率较高。
Ann Neurol. 1997 Jun;41(6):716-21. doi: 10.1002/ana.410410607.
6
Protective effect of apo epsilon 2 in Alzheimer's disease. Oxford Project to Investigate Memory and Ageing (OPTIMA).载脂蛋白ε2在阿尔茨海默病中的保护作用。牛津记忆与衰老研究项目(OPTIMA)。
Lancet. 1994 Aug 13;344(8920):473-4.
7
Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease.易感基因载脂蛋白E-ε4和载脂蛋白E-ε2对晚发性阿尔茨海默病疾病表达率的影响。
Arzneimittelforschung. 1995 Mar;45(3A):413-7.
8
Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects.比利时关于神经退行性和血管性痴呆的前瞻性研究:APOE基因分型的影响。
J Neurol Neurosurg Psychiatry. 2003 Aug;74(8):1148-51. doi: 10.1136/jnnp.74.8.1148.
9
Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians.尼日利亚老年人中载脂蛋白E ε4与阿尔茨海默病之间不存在关联。
Ann Neurol. 1995 Sep;38(3):463-5. doi: 10.1002/ana.410380319.
10
Apolipoprotein E-epsilon 4 allele and Alzheimer's disease.载脂蛋白E-ε4等位基因与阿尔茨海默病。
Lancet. 1993 Nov 20;342(8882):1309.

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Age-dependent interactions of APOE isoform 4 and Alzheimer's disease neuropathology: findings from the NACC.载脂蛋白E异构体4与阿尔茨海默病神经病理学的年龄依赖性相互作用:来自国家阿尔茨海默病协调中心(NACC)的研究结果
Acta Neuropathol Commun. 2025 May 17;13(1):102. doi: 10.1186/s40478-025-02012-0.
2
Ethnic differences in the effects of apolipoprotein E ɛ4 and vascular risk factors on accelerated brain aging.载脂蛋白E ε4及血管危险因素对脑加速老化影响的种族差异
Brain Commun. 2024 Jul 12;6(4):fcae213. doi: 10.1093/braincomms/fcae213. eCollection 2024.
3
APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia.
载脂蛋白 E 等位基因与阿尔茨海默病和相关痴呆症影响的大脑区域的性别特异性结构差异相关。
PLoS Biol. 2022 Dec 13;20(12):e3001863. doi: 10.1371/journal.pbio.3001863. eCollection 2022 Dec.
4
Admixture mapping reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer's disease in Caribbean Hispanics.混合映射揭示了加勒比裔西班牙人群体中 3q13.11 处的美洲原住民血统与阿尔茨海默病风险降低之间的关联。
Alzheimers Res Ther. 2021 Jul 3;13(1):122. doi: 10.1186/s13195-021-00866-9.
5
Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer's Disease Patients and Correlates with Cognitive Performance.阿尔茨海默病患者的血浆高密度脂蛋白小亚型减少,并与认知表现相关。
J Alzheimers Dis. 2020;77(2):733-744. doi: 10.3233/JAD-200291.
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The Association between the Apolipoprotein E Gene Polymorphism and All-cause Mortality in the Korean Population.载脂蛋白 E 基因多态性与韩国人群全因死亡率的关系。
J Korean Med Sci. 2019 Oct 21;34(40):e269. doi: 10.3346/jkms.2019.34.e269.
7
A Novel Apolipoprotein E Antagonist Functionally Blocks Apolipoprotein E Interaction With N-terminal Amyloid Precursor Protein, Reduces β-Amyloid-Associated Pathology, and Improves Cognition.一种新型载脂蛋白 E 拮抗剂能有效阻断载脂蛋白 E 与 N 端淀粉样前体蛋白的相互作用,减少β-淀粉样蛋白相关病理,改善认知。
Biol Psychiatry. 2019 Aug 1;86(3):208-220. doi: 10.1016/j.biopsych.2019.04.026. Epub 2019 May 2.
8
Racial Differences in the Association Between Apolipoprotein E Risk Alleles and Overall and Total Cardiovascular Mortality Over 18 Years.载脂蛋白E风险等位基因与18年全因心血管死亡率及总心血管死亡率之间关联的种族差异
J Am Geriatr Soc. 2017 Nov;65(11):2425-2430. doi: 10.1111/jgs.15059. Epub 2017 Sep 12.
9
The Effect of Apolipoprotein E ε4 (APOE ε4) on Visuospatial Working Memory in Healthy Elderly and Amnestic Mild Cognitive Impairment Patients: An Event-Related Potentials Study.载脂蛋白Eε4(APOEε4)对健康老年人和遗忘型轻度认知障碍患者视觉空间工作记忆的影响:一项事件相关电位研究。
Front Aging Neurosci. 2017 May 17;9:145. doi: 10.3389/fnagi.2017.00145. eCollection 2017.
10
Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer's disease data set.在一个病例对照阿尔茨海默病数据集中对MS4A和TREM基因簇进行突变分析。
Neurobiol Aging. 2016 Jun;42:217.e7-217.e13. doi: 10.1016/j.neurobiolaging.2016.03.009. Epub 2016 Mar 21.