Omene J A, Easington C R, Glew R H, Prosper M, Ledlie S
Department of Ambulatory Care, Woodhull Medical and Mental Health Center, Brooklyn, New York 11206, USA.
J Natl Med Assoc. 1996 Dec;88(12):789-93.
Representative levels of serum micronutrients specifically, beta-carotene and vitamins A and E, were studied in symptomatic human immunodeficiency virus (HIV)-infected children. The nutritional status of 23 symptomatic African-American and Hispanic HIV-infected children were compared with an appropriate control group comprised of 36 uninfected children matched for age and sex, using body mass index. Serum beta-carotene and vitamin A and E levels were randomly determined on 15 of the infected children. Beta-carotene concentration was 4.9-fold reduced in symptomatic HIV-infected children when compared with the control group. There was a 6.5-fold decrease in the serum level for children without acquired immunodeficiency syndrome (AIDS) and a 13-fold reduction in children with AIDS. No differences in the mean values for serum vitamins A and E were observed in the groups studied. Although the nutritional status of the symptomatic HIV-infected children was not different from that of the control population, their serum beta-carotene levels were profoundly deficient. This finding may have immunologic and clinical implications for children with rapidly progressing HIV disease.
对有症状的人类免疫缺陷病毒（HIV）感染儿童的血清微量营养素（特别是β-胡萝卜素以及维生素A和E）的代表性水平进行了研究。使用体重指数，将23名有症状的非裔美国人和西班牙裔HIV感染儿童的营养状况与由36名年龄和性别匹配的未感染儿童组成的适当对照组进行了比较。对15名感染儿童随机测定血清β-胡萝卜素、维生素A和E水平。与对照组相比，有症状的HIV感染儿童的β-胡萝卜素浓度降低了4.9倍。未患获得性免疫缺陷综合征（AIDS）的儿童血清水平下降了6.5倍，患AIDS的儿童下降了13倍。在所研究的组中，未观察到血清维生素A和E平均值的差异。尽管有症状的HIV感染儿童的营养状况与对照人群没有差异，但他们的血清β-胡萝卜素水平严重不足。这一发现可能对快速进展的HIV疾病儿童具有免疫学和临床意义。
