Barrioz T, Ingrand P, Besson I, de Ledinghen V, Silvain C, Beauchant M
Hepatology Unit, University Hospital, Poitiers, France.
Lancet. 1994 Aug 27;344(8922):581-2. doi: 10.1016/s0140-6736(94)91967-4.
Biliary stents are liable to clog. We investigated whether a choleretic plus an antibiotic could delay clogging. 20 consecutive patients with a malignant biliary stricture were randomised after endoscopic insertion of a polyethylene stent to receive ursodeoxycholic acid plus norfloxacin (13-15 mg/kg and 400 mg, daily) or conservative treatment. The drug combination was associated with: a longer median patency of first (49 vs 6 weeks) and all stents (38 vs 7 weeks); a prolonged median survival (67 vs 18 weeks); and a shorter mean hospital stay (0.2 vs 1.0 days per week of survival). Thus ursodeoxycholic acid plus norfloxacin may prevent stent clogging.
胆管支架容易堵塞。我们研究了一种利胆剂加一种抗生素是否能延缓堵塞。20例连续性恶性胆管狭窄患者在内镜插入聚乙烯支架后，被随机分为两组，分别接受熊去氧胆酸加利氟沙星（每日13 - 15毫克/千克和400毫克）或保守治疗。药物联合治疗的结果如下：首次置入支架的中位通畅时间更长（49周对6周），所有支架的中位通畅时间也更长（38周对7周）；中位生存期延长（67周对18周）；平均住院时间缩短（每生存一周为0.2天对1.0天）。因此，熊去氧胆酸加利氟沙星可能预防支架堵塞。
