使用周期性抗生素和熊去氧胆酸预防胆管支架阻塞
Prevention of biliary stent occlusion using cyclical antibiotics and ursodeoxycholic acid.
作者信息
Ghosh S, Palmer K R
机构信息
Gastrointestinal Unit, Western General Hospital, Edinburgh.
出版信息
Gut. 1994 Dec;35(12):1757-9. doi: 10.1136/gut.35.12.1757.
Abstract
This study reports an open randomised controlled trial of cyclical antibiotics and ursodeoxycholic acid in prevention of plastic biliary stent occlusion. Seventy patients with malignant distal bile duct obstruction were randomised to either active treatment with cyclical antibiotics (ampicillin, metronidazole, ciprofloxacin) and ursodeoxycholic acid or no treatment after successful stent insertion. The two groups were well matched. The follow up was complete with stent occlusion or death being the end points. There was no difference in the incidence of stent occlusion between the two groups and the overall survival was similar. In conclusion, this study did not show any benefit of treatment with antibiotics and ursodeoxycholic acid in prolonging stent patency or improving survival.
摘要
本研究报告了一项关于周期性使用抗生素和熊去氧胆酸预防塑料胆管支架阻塞的开放性随机对照试验。70例恶性远端胆管梗阻患者在成功置入支架后，被随机分为接受周期性抗生素（氨苄西林、甲硝唑、环丙沙星）和熊去氧胆酸的积极治疗组或不治疗组。两组匹配良好。随访完整，以支架阻塞或死亡作为终点。两组之间支架阻塞的发生率没有差异，总生存率相似。总之，本研究未显示抗生素和熊去氧胆酸治疗在延长支架通畅时间或改善生存率方面有任何益处。
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