• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Prevention of biliary stent occlusion using cyclical antibiotics and ursodeoxycholic acid.使用周期性抗生素和熊去氧胆酸预防胆管支架阻塞
Gut. 1994 Dec;35(12):1757-9. doi: 10.1136/gut.35.12.1757.
2
Ofloxacin and ursodeoxycholic acid versus ursodeoxycholic acid alone to prevent occlusion of biliary stents: a prospective, randomized trial.
Endoscopy. 2001 Jun;33(6):491-4. doi: 10.1055/s-2001-14963.
3
Comparison of treatment outcomes between biliary plastic stent placements with and without endoscopic sphincterotomy for inoperable malignant common bile duct obstruction.对于无法手术的恶性胆总管梗阻患者，有内镜括约肌切开术与无内镜括约肌切开术的胆道塑料支架置入治疗效果比较
World J Gastroenterol. 2004 Apr 15;10(8):1212-4. doi: 10.3748/wjg.v10.i8.1212.
4
[Prevention of clogging of biliary stents by administration of levofloxacin and ursodeoxycholic acid].[通过给予左氧氟沙星和熊去氧胆酸预防胆道支架堵塞]
Chir Ital. 2004 Nov-Dec;56(6):831-7.
5
Tannenbaum and metal stents in the palliative treatment of malignant distal bile duct obstruction: a comparative study of patency and cost effectiveness.坦嫩鲍姆支架与金属支架在恶性远端胆管梗阻姑息治疗中的应用：通畅率及成本效益的比较研究
Surg Endosc. 2006 Oct;20(10):1587-93. doi: 10.1007/s00464-005-0778-1. Epub 2006 Aug 7.
6
Malignant obstruction of the common bile duct: long-term results of Gianturco-Rosch metal stents used as initial treatment.
Radiology. 1994 Sep;192(3):663-7. doi: 10.1148/radiology.192.3.7520181.
7
Treatment of malignant biliary obstruction with polyurethane-covered Wallstents.用聚氨酯覆膜Wallstents治疗恶性胆道梗阻
AJR Am J Roentgenol. 1998 Feb;170(2):403-8. doi: 10.2214/ajr.170.2.9456954.
8
Paclitaxel-eluting covered metal stents versus covered metal stents for distal malignant biliary obstruction: a prospective comparative pilot study.紫杉醇洗脱覆膜金属支架与覆膜金属支架治疗远端恶性胆道梗阻的前瞻性对照初步研究。
Gastrointest Endosc. 2011 Apr;73(4):727-33. doi: 10.1016/j.gie.2010.11.048. Epub 2011 Feb 2.
9
Ursodeoxycholic acid and/or antibiotics for prevention of biliary stent occlusion.熊去氧胆酸和/或抗生素用于预防胆管支架阻塞。
Cochrane Database Syst Rev. 2002;2002(3):CD003043. doi: 10.1002/14651858.CD003043.
10
Meta-analysis of randomized trials comparing the patency of covered and uncovered self-expandable metal stents for palliation of distal malignant bile duct obstruction.比较覆盖式和非覆盖式自膨式金属支架治疗远端恶性胆管梗阻的缓解效果的随机试验的荟萃分析。
Gastrointest Endosc. 2011 Aug;74(2):321-327.e1-3. doi: 10.1016/j.gie.2011.03.1249. Epub 2011 Jun 17.

引用本文的文献

1
The perfect biliary plastic stent: the search goes on.完美的胆道塑料支架：探索仍在继续。
Ann Gastroenterol. 2023 Sep-Oct;36(5):490-496. doi: 10.20524/aog.2023.0826. Epub 2023 Jul 25.
2
Advancements in Endoscopic Biliary Interventions by Gastroenterology.胃肠病学在内镜下胆道介入治疗方面的进展。
Semin Intervent Radiol. 2021 Aug;38(3):280-290. doi: 10.1055/s-0041-1731266. Epub 2021 Aug 10.
3
Metallic Stent Mesh Coated with Silver Nanoparticles Suppresses Stent-Induced Tissue Hyperplasia and Biliary Sludge in the Rabbit Extrahepatic Bile Duct.涂有银纳米颗粒的金属支架网可抑制兔肝外胆管中支架诱导的组织增生和胆泥形成。
Pharmaceutics. 2020 Jun 17;12(6):563. doi: 10.3390/pharmaceutics12060563.
4
Impact of biliary stent-related events in patients diagnosed with advanced pancreatobiliary tumours receiving palliative chemotherapy.胆道支架相关事件对接受姑息化疗的晚期胰胆管肿瘤患者的影响。
World J Gastroenterol. 2016 Jul 14;22(26):6065-75. doi: 10.3748/wjg.v22.i26.6065.
5
A comparative evaluation of early stent occlusion among biliary conventional versus wing stents.胆管传统支架与翼型支架早期支架闭塞的对比评价。
Dig Dis Sci. 2012 Jun;57(6):1708-16. doi: 10.1007/s10620-012-2048-0. Epub 2012 Jan 20.
6
Plastic biliary stent occlusion: factors involved and possible preventive approaches.塑料胆管支架阻塞：相关因素及可能的预防方法。
Clin Med Res. 2007 Mar;5(1):53-60. doi: 10.3121/cmr.2007.683.
7
Antireflux biliary stents: are they the solution to stent occlusions?抗反流胆管支架：它们是解决支架堵塞的办法吗？
Curr Gastroenterol Rep. 2006 Apr;8(2):156-60. doi: 10.1007/s11894-006-0012-x.
8
Ursodeoxycholic acid and/or antibiotics for prevention of biliary stent occlusion.熊去氧胆酸和/或抗生素用于预防胆管支架阻塞。
Cochrane Database Syst Rev. 2002;2002(3):CD003043. doi: 10.1002/14651858.CD003043.
9
Prevention of biliary stent occlusion by ursodeoxycholic acid plus norfloxacin: a multicenter randomized trial.熊去氧胆酸联合诺氟沙星预防胆管支架阻塞：一项多中心随机试验
Dig Dis Sci. 2000 Jan;45(1):145-50. doi: 10.1023/a:1005429914955.
10
[1997 gastroenterology update--II].[1997年胃肠病学进展——II]
Med Klin (Munich). 1998 Mar 15;93(3):146-64. doi: 10.1007/BF03044832.

本文引用的文献

1
A prospective, randomized, controlled trial of metal stents for malignant obstruction of the common bile duct.一项关于金属支架治疗胆总管恶性梗阻的前瞻性、随机对照试验。
Endoscopy. 1993 Mar;25(3):207-12. doi: 10.1055/s-2007-1010294.
2
Optimal timing for stent replacement in malignant biliary tract obstruction.
Gastrointest Endosc. 1993 Mar-Apr;39(2):164-7. doi: 10.1016/s0016-5107(93)70058-9.
3
Kinetics of hepatic bile acid handling in cholestatic liver disease: effect of ursodeoxycholic acid.胆汁淤积性肝病中肝脏胆汁酸处理的动力学：熊去氧胆酸的作用
Gastroenterology. 1994 Jan;106(1):134-42. doi: 10.1016/s0016-5085(94)94899-2.
4
Ursodeoxycholic acid: a review of its pharmacological properties and therapeutic efficacy.熊去氧胆酸：其药理特性与治疗效果综述
Drugs. 1984 Feb;27(2):95-131. doi: 10.2165/00003495-198427020-00001.
5
Bacterial biofilms in nature and disease.自然与疾病中的细菌生物膜
Annu Rev Microbiol. 1987;41:435-64. doi: 10.1146/annurev.mi.41.100187.002251.
6
The role of bacteria in the blockage of biliary stents.
Gastrointest Endosc. 1988 Jan-Feb;34(1):19-22. doi: 10.1016/s0016-5107(88)71223-7.
7
A placebo-controlled study on the efficacy of aspirin and doxycycline in preventing clogging of biliary endoprostheses.
Gastrointest Endosc. 1989 Nov-Dec;35(6):485-9. doi: 10.1016/s0016-5107(89)72895-9.
8
Endoscopic management of malignant biliary obstruction: stents of 10 French gauge are preferable to stents of 8 French gauge.恶性胆管梗阻的内镜治疗：10法式规格的支架优于8法式规格的支架。
Gastrointest Endosc. 1988 Sep-Oct;34(5):412-7. doi: 10.1016/s0016-5107(88)71407-8.
9
Biliary stent blockage with bacterial biofilm. A light and electron microscopy study.伴有细菌生物膜的胆管支架阻塞：一项光镜和电镜研究
Ann Intern Med. 1988 Apr;108(4):546-53. doi: 10.7326/0003-4819-108-4-546.
10
Factors affecting the patency of stents in malignant biliary obstructive disease: univariate and multivariate analysis.
Am J Gastroenterol. 1991 Jul;86(7):843-9.

使用周期性抗生素和熊去氧胆酸预防胆管支架阻塞

Prevention of biliary stent occlusion using cyclical antibiotics and ursodeoxycholic acid.

作者信息

Ghosh S, Palmer K R

机构信息

Gastrointestinal Unit, Western General Hospital, Edinburgh.

出版信息

Gut. 1994 Dec;35(12):1757-9. doi: 10.1136/gut.35.12.1757.

DOI:10.1136/gut.35.12.1757
PMID:7829015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1375266/
Abstract

This study reports an open randomised controlled trial of cyclical antibiotics and ursodeoxycholic acid in prevention of plastic biliary stent occlusion. Seventy patients with malignant distal bile duct obstruction were randomised to either active treatment with cyclical antibiotics (ampicillin, metronidazole, ciprofloxacin) and ursodeoxycholic acid or no treatment after successful stent insertion. The two groups were well matched. The follow up was complete with stent occlusion or death being the end points. There was no difference in the incidence of stent occlusion between the two groups and the overall survival was similar. In conclusion, this study did not show any benefit of treatment with antibiotics and ursodeoxycholic acid in prolonging stent patency or improving survival.

摘要

本研究报告了一项关于周期性使用抗生素和熊去氧胆酸预防塑料胆管支架阻塞的开放性随机对照试验。70例恶性远端胆管梗阻患者在成功置入支架后，被随机分为接受周期性抗生素（氨苄西林、甲硝唑、环丙沙星）和熊去氧胆酸的积极治疗组或不治疗组。两组匹配良好。随访完整，以支架阻塞或死亡作为终点。两组之间支架阻塞的发生率没有差异，总生存率相似。总之，本研究未显示抗生素和熊去氧胆酸治疗在延长支架通畅时间或改善生存率方面有任何益处。