Draehmpaehl D
Institut für Anatomie, Veterinärmedizinische Fakultät, Freien Universität Berlin.
Berl Munch Tierarztl Wochenschr. 1994 May;107(5):157-62.
Four guinea pigs were immunized against sperms from their own epididymis. The titers of autoantibodies against the sperms in the tubuli of the parenchyma testis increased after 4 weeks. The heads of sperms were also gummed up. The left testis of another 7 guinea pigs were shifted into the abdominal cavity. These animals showed also increasing autoantibody-titer. The observations demonstrated, that the blood-testis-barrier is a physiological one for the autoantibodies. At higher temperatures, as with cryptorchid testes, this barrier becomes permeable for antibodies so that infertility can result.
四只豚鼠用自身附睾精子进行免疫。4周后，实质睾丸小管中针对精子的自身抗体滴度升高。精子头部也出现黏连。另外7只豚鼠的左侧睾丸被移入腹腔。这些动物的自身抗体滴度也出现升高。观察结果表明，血睾屏障对自身抗体而言是一种生理屏障。在较高温度下，如隐睾症时，这种屏障对抗体变得可通透，从而可能导致不育。
