Luengo L, Vicente V, Gris F, Coronas J M, Escuder J, Ramón Gomez J, Castellote J M
Hospital de Tarragona Joan XXIII, Facultad de Medicina, Department of Surgery, University of Barcelona, Spain.
Int J Pancreatol. 1994 Apr;15(2):139-44. doi: 10.1007/BF02924664.
A prospective, controlled, and randomized clinical study was carried out with the purpose of evaluating the influence of somatostatin in the evolution of acute pancreatitis. One hundred patients were randomly divided into two groups, a control group (n = 50 patients) and a somatostatin group (n = 50 patients to whom a dosage of 250 micrograms/h was administered for 48 h following a bolus of 250 micrograms at the beginning of therapy). The two groups were homogeneous in age, sex, etiology, and severity of clinical picture (on admission). The following parameters were compared in the two groups: 1. Evolution of the Computerized Axial Tomography (CT) findings on admission and after 48 h; 2. Length of hospital stay; 3. Need for surgery; and 4. Mortality. The results from the CT scans showed a significant statistical difference in favor of somatostatin regarding the evolution of pancreatic lesions and length of stay in the hospital. Another study using a larger sample would be required in order to evaluate the rest of the parameters.
为了评估生长抑素对急性胰腺炎病程的影响，开展了一项前瞻性、对照、随机临床研究。100例患者被随机分为两组，即对照组（n = 50例患者）和生长抑素组（n = 50例患者，在治疗开始时静脉推注250微克后，以250微克/小时的剂量给药48小时）。两组在年龄、性别、病因及入院时临床表现的严重程度方面具有同质性。对两组的以下参数进行了比较：1. 入院时及48小时后计算机断层扫描（CT）结果的变化；2. 住院时间；3. 手术需求；4. 死亡率。CT扫描结果显示，在胰腺病变的演变及住院时间方面，生长抑素组具有显著统计学差异。为了评估其他参数，需要开展另一项样本量更大的研究。
