Tung K S, Cooke W D, McCarty T A, Robitaille P
Clin Exp Immunol. 1976 Jul;25(1):73-9.
Naturally occurring human antisperm antibodies (ASA) detectable by immunofluorescence, were found to have a peak indicence of 90% in both sexes before puberty. Thereafter, the incidence declined to about 60% and persisted through life. This age-related incidence resembled that for foreign and not self antigens. The natural incidence of the six antibodies under investigation varied: the most frequent were antibodies to acrosomal antigen Acl and equatorial antigen; the least frequent were antibodies to acrosomal antigen Ac2 and sperm nuclear protamine; and between these were antibodies to the mainpiece of tail and post-acrosomal region. Irrespective of their natural incidence, these antibodies increased at a comparable rate in men following vasectomy indicating these six sperm antigens have comparable immunogenicity. These results provide evidence for the lack of immunologic tolerance in man toward many sperm antigens. The variation in the natural incidence of individual ASA is explanable by differences in prevalence of crossreaction between each sperm antigen with exogenous antigens. Thus, antibodies to acrosomal antigen Acl and equatorial antigen, which occurred most frequently, appeared to crossreact with ubiquitous microorganisms.
通过免疫荧光检测发现，自然产生的人类抗精子抗体（ASA）在青春期前两性中的峰值发生率均为90%。此后，发生率降至约60%，并持续终生。这种与年龄相关的发生率类似于对外源而非自身抗原的发生率。所研究的六种抗体的自然发生率各不相同：最常见的是针对顶体抗原Acl和赤道抗原的抗体；最不常见的是针对顶体抗原Ac2和精子核鱼精蛋白的抗体；介于两者之间的是针对尾部主段和顶体后区域的抗体。无论其自然发生率如何，输精管结扎术后男性体内这些抗体的增加速率相当，表明这六种精子抗原具有相当的免疫原性。这些结果为人类对许多精子抗原缺乏免疫耐受性提供了证据。个体ASA自然发生率的差异可以通过每种精子抗原与外源抗原之间交叉反应发生率的差异来解释。因此，最常出现的针对顶体抗原Acl和赤道抗原的抗体似乎与普遍存在的微生物发生交叉反应。
