细菌黏附与黏膜细胞因子产生。

Bacterial adherence and mucosal cytokine production.

Svanborg C, Agace W, Hedges S, Lindstedt R, Svensson M L

Department of Medical Microbiology, Lund University, Sweden.

Ann N Y Acad Sci. 1994 Aug 15;730:162-81. doi: 10.1111/j.1749-6632.1994.tb44247.x.

Abstract

Uropathogenic E. coli adhere to mucosal sites. 2. In the urinary tract, adherence is followed by inflammation, including a mucosal cytokine response. 3. Bacteria activate epithelial cells to secrete IL-6 and IL-8. IL-6 may cause the fever and acute phase response that accompany systemic urinary tract infections. IL-8 may function as a neutrophil chemoattractant. 4. E. coli up-regulate adhesion molecule expression on epithelial cell lines and neutrophil migration through epithelial cell monolayers. This process is inhibited by antibodies to CD18 and ICAM-1. 5. Cytokines released by nonepithelial cells (T cells and monocytes) modify the epithelial cell cytokine response to bacteria.

摘要

尿路致病性大肠杆菌黏附于黏膜部位。2. 在尿路中，黏附之后会引发炎症，包括黏膜细胞因子反应。3. 细菌激活上皮细胞分泌白细胞介素-6（IL-6）和白细胞介素-8（IL-8）。IL-6 可能引发伴随全身性尿路感染的发热和急性期反应。IL-8 可能起到中性粒细胞趋化因子的作用。4. 大肠杆菌上调上皮细胞系上黏附分子的表达，并促进中性粒细胞穿过上皮细胞单层迁移。这一过程受到针对 CD18 和细胞间黏附分子-1（ICAM-1）的抗体的抑制。5. 非上皮细胞（T 细胞和单核细胞）释放的细胞因子会改变上皮细胞对细菌的细胞因子反应。