可溶性细胞间黏附分子-1对鼻病毒参考毒株和临床分离株的活性谱
Spectrum of activity of soluble intercellular adhesion molecule-1 against rhinovirus reference strains and field isolates.
作者信息
Ohlin A, Hoover-Litty H, Sanderson G, Paessens A, Johnston S L, Holgate S T, Huguenel E, Greve J M
机构信息
Institute for Inflammation and Experimental Medicine, Miles Biotechnology, West Haven, Connecticut 06516.
出版信息
Antimicrob Agents Chemother. 1994 Jun;38(6):1413-5. doi: 10.1128/AAC.38.6.1413.
Abstract
The antiviral potency of soluble intercellular adhesion molecule-1 (ICAM-1; the major receptor for human rhinoviruses) was determined for a subset of American Type Culture Collection reference serotypes and field isolates of rhinovirus. The results indicate that soluble ICAM-1 exhibits a broad spectrum of activity against rhinoviruses and that field isolates have a sensitivity indistinguishable from that of laboratory strains.
摘要
针对美国典型培养物保藏中心参考血清型和鼻病毒野毒株的一个子集，测定了可溶性细胞间粘附分子-1（ICAM-1；人鼻病毒的主要受体）的抗病毒效力。结果表明，可溶性ICAM-1对鼻病毒表现出广谱活性，且野毒株的敏感性与实验室菌株无异。
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