Dearden C, al-Nakib W, Andries K, Woestenborghs R, Tyrrell D A
MRC Common Cold Unit, Salisbury, England.
Arch Virol. 1989;109(1-2):71-81. doi: 10.1007/BF01310519.
Viruses were isolated from nasal washings of volunteers receiving experimental therapy for rhinovirus type 9 infection with intranasal sprays of a new synthetic antiviral R61837. On a screening test nine subjects yielded drug sensitive virus and four resistant virus. In four others the virus was sensitive at first but became resistant later, while in one the reverse occurred. Evidence is given that at least some of the resistant viruses were present in the respiratory tract and were not selected during virus isolation. Of six viruses studied in detail, five had a low degree of resistance and one was highly resistant. The degree of resistance of the five was similar for an antiviral chalcone, dichloroflavan and disoxaril. The sixth was different in that the resistance to disoxaril was relatively less than to the other drugs. The significance of these results is discussed--these are the first experiments in man to show the selection of drug resistant rhinovirus.
从接受新型合成抗病毒药物R61837鼻内喷雾治疗9型鼻病毒感染的志愿者的鼻腔冲洗液中分离出病毒。在一项筛选试验中，9名受试者产生了对药物敏感的病毒，4名受试者产生了耐药病毒。另外4名受试者的病毒起初敏感，但后来变得耐药，而有1名受试者情况相反。有证据表明，至少一些耐药病毒存在于呼吸道中，并非在病毒分离过程中被筛选出来。在详细研究的6株病毒中，5株耐药程度较低，1株高度耐药。这5株病毒对一种抗真菌查耳酮、二氯黄烷和双羟萘酸噻嘧啶的耐药程度相似。第6株病毒不同，它对双羟萘酸噻嘧啶的耐药性相对低于对其他药物的耐药性。讨论了这些结果的意义——这些是首次在人体中显示耐药鼻病毒选择的实验。
