Idel H, Stiller-Winkler R, Malin E M, Krämer U
Institut für Hygiene, Heinrich-Heine-Universität Düsseldorf.
Zentralbl Hyg Umweltmed. 1994 Jun;195(5-6):457-62.
The aim of this study was to investigate the relationship between different levels of air pollution and IgG antibody titers against tetanus toxoid in sera of 6 year old children (n = 354). Additionally, other parameters of the humoral immune response (immunoglobulins G, A, M, total IgE, complement component C3c, C-reactive protein (CRP)) were analysed. The index areas were Leipzig, Magdeburg (Saxony/Saxe-Anhalt), and Duisburg, Dortmund (Ruhr region). The control areas were Osterburg and Borken. IgG antibodies against tetanus toxoid were measured by ELISA in sera of children vaccinated three times DPT in early childhood. The other humoral parameters were measured by nephelometry. In comparison to the control area Borken the sera of children living in the index areas Duisburg and Dortmund showed a lower antibody titer. There were no differences between the index areas (Leipzig, Magdeburg) and the control area Osterburg. It has to be taken into account that the choice of Osterburg as a control area is problematic because of the lack of data on air pollution. Statistically, there was no relationship between antibody titer against tetanus toxoid and the additionally measured parameters of the humoral immune response.
本研究旨在调查6岁儿童（n = 354）血清中不同水平的空气污染与破伤风类毒素IgG抗体滴度之间的关系。此外，还分析了体液免疫反应的其他参数（免疫球蛋白G、A、M、总IgE、补体成分C3c、C反应蛋白（CRP））。指标区域为莱比锡、马格德堡（萨克森/萨克森 - 安哈尔特）、杜伊斯堡、多特蒙德（鲁尔区）。对照区域为奥斯特堡和博尔肯。通过ELISA法检测幼儿期接种过三次百白破疫苗的儿童血清中抗破伤风类毒素的IgG抗体。其他体液参数通过比浊法测量。与对照区域博尔肯相比，居住在指标区域杜伊斯堡和多特蒙德的儿童血清抗体滴度较低。指标区域（莱比锡、马格德堡）与对照区域奥斯特堡之间没有差异。必须考虑到，由于缺乏空气污染数据，选择奥斯特堡作为对照区域存在问题。从统计学角度来看，抗破伤风类毒素抗体滴度与额外测量的体液免疫反应参数之间没有关系。
