Pasic J, Shapiro D, Jamner L D, Hui K K
Department of Medicine, University of California, Los Angeles.
Am J Hypertens. 1994 Jun;7(6):503-8. doi: 10.1093/ajh/7.6.503.
Forty-two patients with mild-to-moderate hypertension between the ages of 35 and 65 (23 men, 19 women) were studied to determine whether psychological characteristics can help differentiate between responders and nonresponders to diuretic (hydrochlorothiazide 25 mg and triamterene 50 mg). To qualify for inclusion in the study, the subjects were required to have a mean unmedicated clinic diastolic blood pressure (DBP) between 95 and 110 mm Hg. Positive response to diuretic was defined as a reduction in clinic DBP < or = 90 mm Hg. Of the 42 subjects, 22 were responders to diuretic, achieving a BP level of 129/86 mm Hg, a reduction of 16/11 mm Hg from their unmedicated level. Nonresponders achieved a reduction of 8/4 mm Hg. Compared with nonresponders, responders were characterized by slightly lower initial BP levels and significantly lower scores on the Buss-Durkee Hostility Inventory and several subscales of this test. The pattern of results indicated higher levels of suppressed hostility in the nonresponders. Ambulatory BP data paralleled the clinic BP changes.
对42名年龄在35至65岁之间的轻至中度高血压患者（23名男性，19名女性）进行了研究，以确定心理特征是否有助于区分利尿剂（氢氯噻嗪25毫克和氨苯蝶啶50毫克）治疗的反应者和无反应者。为符合纳入该研究的条件，受试者的平均未服药时门诊舒张压（DBP）需在95至110毫米汞柱之间。对利尿剂的阳性反应定义为门诊DBP降低至≤90毫米汞柱。在这42名受试者中，22名是利尿剂治疗的反应者，血压水平达到129/86毫米汞柱，较未服药时降低了16/11毫米汞柱。无反应者血压降低了8/4毫米汞柱。与无反应者相比，反应者的初始血压水平略低，在Buss-Durkee敌意量表及其几个子量表上的得分显著更低。结果模式表明无反应者的压抑敌意水平更高。动态血压数据与门诊血压变化情况相似。
