Asakura K, Narita S, Kojima T, Saito H, Kataura A
Department of Otolaryngology, Sapporo Medical College, Japan.
Eur Arch Otorhinolaryngol. 1994;251(4):224-8. doi: 10.1007/BF00628428.
We studied serial changes of nasal airway resistance (NAR) and secretory response after topical stimulation with either capsaicin or histamine, since both are known to stimulate a chemosensitive sensory C-fiber ending. After topical capsaicin stimulation, a dose-related increase of NAR was noted, with a peak response occurring at 10-20 min. These NAR responses were completely abolished following systemic pretreatment with capsaicin. However, they were not affected by atropine, diphenhydramine or hexamethonium pretreatment. After topical histamine stimulation, an atropine-resistant increase of NAR was found and continued more than 120 min. The early phase of this response was significantly suppressed by the systemic pretreatment with capsaicin. A secretory response also occurred after topical capsaicin stimulation and continued for 30 min. This secretory response was almost completely blocked by atropine, hexamethonium or systemic capsaicin pretreatment and was partially suppressed by diphenhydramine pretreatment. These findings suggest that sensory C-fiber stimulation can induce both atropine-resistant vascular reflexes and atropine-sensitive secretory reflexes, and that these reflexes might play an important role during the early phase after nasal stimulation.
我们研究了用辣椒素或组胺局部刺激后鼻气道阻力（NAR）的系列变化和分泌反应，因为已知这两种物质均可刺激化学敏感的感觉C纤维末梢。局部应用辣椒素刺激后，观察到NAR呈剂量相关增加，在10 - 20分钟时出现峰值反应。在用辣椒素进行全身预处理后，这些NAR反应完全消失。然而，它们不受阿托品、苯海拉明或六甲铵预处理的影响。局部应用组胺刺激后，发现NAR出现阿托品抵抗性增加，并持续超过120分钟。该反应的早期阶段被辣椒素全身预处理显著抑制。局部应用辣椒素刺激后也出现分泌反应，并持续30分钟。这种分泌反应几乎完全被阿托品、六甲铵或全身辣椒素预处理阻断，而被苯海拉明预处理部分抑制。这些发现表明，感觉C纤维刺激可诱导阿托品抵抗性血管反射和阿托品敏感性分泌反射，并且这些反射可能在鼻刺激后的早期阶段发挥重要作用。
