Minton A P
Section on Physical Biochemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
J Mol Recognit. 1993 Dec;6(4):211-4. doi: 10.1002/jmr.300060410.
The effects of macromolecular crowding upon macromolecular associations in solution, and upon binding of a macromolecular ligand to a surface site, are reviewed. It is demonstrated, by means of two examples, that crowding may lead to significant alterations of biochemical or biological recognition processes at the molecular level.
本文综述了大分子拥挤对溶液中大分子缔合以及大分子配体与表面位点结合的影响。通过两个例子表明，拥挤可能导致分子水平上生化或生物识别过程的显著改变。
