Patriarca C, Verdier F, Brouland J P, Vial T, Descotes J
Laboratoire d'Immunotoxicologie Fondamentale et Clinique, INSERM U80, Faculté de Médecine A. Carrel, Lyon, France.
Hum Exp Toxicol. 1994 Jul;13(7):455-60. doi: 10.1177/096032719401300701.
Outbred (namely Wistar and Sprague-Dawley) and inbred (Wistar-Furth, Lewis, Fisher 344 and Brown-Norway) strains of rats were screened for their responses to reference compounds in the popliteal lymph node (PLN) assay. Streptozotocin and diphenylhydantoin gave positive responses as evidenced by increased weight and cellularity indices in all strains used whereas procainamide, isoniazid and barbital consistently gave negative responses. Although these findings overall are in agreement with previous investigations involving these compounds, the lack of marked interstrain differences in PLN responses argues against a strong immunogenetically controlled mechanism as could be assumed in presumably auto-immune reactions. The question is raised whether drug-induced side-effects predicted by the PLN assay are basically non-autoimmune as suggested by clinical and immunological findings in man.
对远交系（即Wistar和Sprague-Dawley）和近交系（Wistar-Furth、Lewis、Fisher 344和Brown-Norway）大鼠在腘窝淋巴结（PLN）试验中对参考化合物的反应进行了筛选。链脲佐菌素和苯妥英产生了阳性反应，在所使用的所有品系中，淋巴结重量增加和细胞指数增加证明了这一点，而普鲁卡因胺、异烟肼和巴比妥始终产生阴性反应。尽管这些发现总体上与先前涉及这些化合物的研究一致，但PLN反应中缺乏明显的品系间差异，这与推测可能是自身免疫反应中可能假设的强大免疫遗传控制机制相悖。有人提出一个问题，即PLN试验预测的药物诱导副作用是否如人体临床和免疫学发现所表明的那样基本上是非自身免疫性的。
