IgA肾病与脾切除术后特发性血小板减少性紫癜：一例报告
IgA nephropathy and idiopathic thrombocytopenic purpura with splenectomy: a case report.
作者信息
Morino M, Inami K, Shibuya A, Sasaki N
机构信息
Department of Paediatrics, Saitama Medical School, Japan.
出版信息
Pediatr Nephrol. 1994 Jun;8(3):345-6. doi: 10.1007/BF00866358.
PMID:7917864
Abstract
A 14-year-old boy who had had a splenectomy at the age of 2 years for idiopathic thrombocytopenic purpura, suffered from IgA nephropathy. Serum IgA and IgE levels were elevated and low levels of circulating immune complexes were detected. Splenectomy may play a role in the pathogenesis or susceptibility to IgA nephropathy by means of decreased clearance of circulating immune complexes or impaired immune regulation, such as increased IgA synthesis.
摘要
一名14岁男孩，2岁时因特发性血小板减少性紫癜接受了脾切除术，现患有IgA肾病。血清IgA和IgE水平升高，检测到循环免疫复合物水平较低。脾切除术可能通过降低循环免疫复合物的清除率或损害免疫调节（如IgA合成增加），在IgA肾病的发病机制或易感性中发挥作用。
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