Geijer T, Neiman J, Rydberg U, Gyllander A, Jönsson E, Sedvall G, Valverius P, Terenius L
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Eur Arch Psychiatry Clin Neurosci. 1994;244(1):26-32. doi: 10.1007/BF02279808.
Alterations in the dopamine system have been hypothesized as a predisposing factor in alcoholism. The presence of the TaqI A1 and B1 alleles adjacent to the dopamine D 2-receptor gene (DRD2) was studied in Scandinavian alcoholic inpatients (n = 74), alcoholics autopsied at a forensic clinic (n = 19) and controls (n = 81). There were no significant differences between controls and the alcoholics, but a tendency of increased DRD2 TaqI A1 or B1 allele frequencies in alcoholic groups selected for severity (i.e. severity according to DSM-III-R criteria, early onset or severe medical complications due to alcohol abuse) and decreased frequencies in the corresponding less severe alcoholic group. The present study does not yield evidence for the hypothesis of an association between the DRD2 TaqI A1 or B1 alleles and alcoholism.
多巴胺系统的改变被认为是酗酒的一个易感因素。在斯堪的纳维亚的酒精中毒住院患者（n = 74）、在法医诊所进行尸检的酗酒者（n = 19）以及对照组（n = 81）中，研究了与多巴胺D2受体基因（DRD2）相邻的TaqI A1和B1等位基因的存在情况。对照组和酗酒者之间没有显著差异，但在根据严重程度选择的酗酒组（即根据DSM-III-R标准的严重程度、早发或因酒精滥用导致的严重医学并发症）中，DRD2 TaqI A1或B1等位基因频率有增加的趋势，而在相应的不太严重的酗酒组中频率降低。本研究没有为DRD2 TaqI A1或B1等位基因与酗酒之间存在关联的假设提供证据。
