Eppley B L, Sadove A M
Division of Plastic and Reconstructive Surgery, Indiana University Medical Center, Indianapolis 46202-5200.
J Craniofac Surg. 1994 May;5(2):110-4; discussion 115. doi: 10.1097/00001665-199405000-00012.
On the basis of previous experimental work in young rabbits, modifications in the polymer fixation used (i.e., smaller plate size, change in ratio of polymer components) were studied for potential alleviation of known growth restriction in this model. Ten juvenile rabbits with metallic markers placed at the calvarial sutural junctions were plated across the left coronal suture. At 6 months of age, measurements were taken of both intermarker distances radiographically (growth) and the plates directly. Unlike previous reports, these resorbable plates permitted symmetrical frontal bone development, unaffected growth across the coronal suture, and a histologically normal underlying suture. These changes appear to be the result of elongation of the fixation plate across a growth site. These results indicate that the change in shape of resorbable fixation after initiation of degradation is more important than complete degradation of the material in rapidly growing bone sites.
基于先前在幼兔身上进行的实验工作，研究了所用聚合物固定方式的改进（即更小的钢板尺寸、聚合物成分比例的改变），以期缓解该模型中已知的生长受限问题。十只在颅缝交界处放置了金属标记物的幼兔，其左侧冠状缝处被植入了钢板。在6个月大时，通过X射线摄影测量了标记物间的距离（生长情况）以及钢板本身。与之前的报告不同，这些可吸收钢板允许额骨对称发育，冠状缝处的生长未受影响，且其下方的缝线在组织学上正常。这些变化似乎是固定钢板在生长部位伸长的结果。这些结果表明，在快速生长的骨部位，可吸收固定物在降解开始后形状的改变比材料的完全降解更为重要。
