Eppley B L, Sadove A M
Division of Plastic Surgery, Indiana University Medical Center, Indianapolis, USA.
Plast Reconstr Surg. 1995 Aug;96(2):316-22. doi: 10.1097/00006534-199508000-00009.
The effects of a resorbable fixation plate composed of a polylactic acid-polyglycolic acid copolymer were compared with those of a metallic fixation plate of similar dimensions in an animal calvarial bone-graft healing model. Bilateral parietal bone grafts in 20 mature rabbits were fixed into position with a titanium mesh plate on one side and a polymer mesh plate on the other side. After 2, 6, 9, and 12 months, cross-sectional histology was used to compare osteotomy line healing, tissue response to the fixation material, and the amount of resorbable plate degradation. After 2 months, no changes in the dimensions of the resorbable plate were observed. The bone grafts fixed by both metal and polymer plates exhibited incomplete healing along the osteotomy lines. After 6 months, there was a 66 percent reduction in the dimensions of the resorbable plate and vertical shortening of screw length. Complete healing was seen along all osteotomy lines of both bone grafts. After 9 months, less than 1 percent of the resorbable mesh plate remained as a small film underneath a collagenous capsule. No polymer was seen within the confines of the screw holes. After 1 year, no evidence of polymer was seen either on the external cranial surface or within any of the screw holes. Bony union was observed across all osteotomy sites. The screw hole outlines persisted. The resorbable plate demonstrated fixation stability similar to that of metal with comparable osteotomy line healing. No adverse local inflammatory reactions were seen as the polymer composite progressed to complete degradation by 1 year.
在动物颅骨骨移植愈合模型中，将由聚乳酸 - 聚乙醇酸共聚物组成的可吸收固定板的效果与尺寸相似的金属固定板的效果进行了比较。在20只成年兔的双侧顶骨上，一侧用钛网板固定骨移植，另一侧用聚合物网板固定。在2、6、9和12个月后，采用横断面组织学方法比较截骨线愈合情况、组织对固定材料的反应以及可吸收板的降解量。2个月后，未观察到可吸收板尺寸的变化。金属板和聚合物板固定的骨移植在截骨线处均表现出不完全愈合。6个月后，可吸收板的尺寸减少了66%，螺钉长度垂直缩短。两块骨移植的所有截骨线均可见完全愈合。9个月后，不到1%的可吸收网板作为胶原囊下的一小片薄膜残留。在螺钉孔范围内未见到聚合物。1年后，在颅外表面或任何螺钉孔内均未见到聚合物的迹象。所有截骨部位均观察到骨愈合。螺钉孔轮廓依然存在。可吸收板表现出与金属相似的固定稳定性，截骨线愈合情况相当。随着聚合物复合材料在1年内完全降解，未观察到局部不良炎症反应。
