Chalikian T V, Sarvazyan A P, Breslauer K J
Department of Chemistry, Rutgers, State University of New Jersey, Piscataway 08855.
Biophys Chem. 1994 Aug;51(2-3):89-107; discussion 107-9. doi: 10.1016/0301-4622(94)85007-0.
We review the results of compressibility studies on proteins, nucleic acids, and systematically altered low molecular weight compounds that model the constituents of these biopolymers. The model compound data allow one to define the compressibility properties of water surrounding charged, polar, and nonpolar groups. These results, in conjunction with compressibility data on proteins and nucleic acids, were used to define the properties of water that is perturbed by the presence of these biopolymers in aqueous solutions. Throughout this review, we emphasize the importance of compressibility data for characterizing the hydration properties of solutes (particularly, proteins, nucleic acids, and their constituents), while describing how such data can be interpreted to gain insight into role that hydration can play in modulating the stability of and recognition between biologically important compounds.
我们回顾了对蛋白质、核酸以及模拟这些生物聚合物成分的系统性改变的低分子量化合物的压缩性研究结果。模型化合物数据使人们能够定义围绕带电、极性和非极性基团的水的压缩性特性。这些结果与蛋白质和核酸的压缩性数据相结合，用于定义在水溶液中受这些生物聚合物存在影响而被扰动的水的特性。在本综述中，我们强调压缩性数据对于表征溶质（特别是蛋白质、核酸及其成分）的水合特性的重要性，同时描述如何解释这些数据以深入了解水合作用在调节生物重要化合物的稳定性和识别过程中所起的作用。
