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外用生药的抗炎成分。V. 青木（山茱萸科桃叶珊瑚属青木）的成分及抗炎作用

Anti-inflammatory constituents of topically applied crude drugs. V. Constituents and anti-inflammatory effect of Aoki, Aucuba japonica Thunb.

作者信息

Shimizu M, Tomoo T

机构信息

Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Biol Pharm Bull. 1994 May;17(5):665-7. doi: 10.1248/bpb.17.665.

DOI:10.1248/bpb.17.665
PMID:7920429
Abstract

The Et2O-soluble fraction of the MeOH extract of the leaves of Aucuba japonica Thunb. showed an anti-inflammatory effect when topically applied to rats. E-Phytol, phytone, bis(2-ethylhexyl)phthalate and friedelin were isolated as active anti-inflammatory components inhibiting carrageenin-induced paw edema. The most effective, E-phytol, inhibited histamine-induced paw edema more potently than the compound 48/80-induced edema, suggesting that the mechanism of action is due to inhibition of the H1 receptor.

摘要

日本桃叶珊瑚叶甲醇提取物的乙醚可溶部分局部应用于大鼠时显示出抗炎作用。植醇、植物酮、邻苯二甲酸二（2-乙基己基）酯和蛇麻脂醇被分离为抑制角叉菜胶诱导的爪肿胀的活性抗炎成分。最有效的植醇抑制组胺诱导的爪肿胀比化合物48/80诱导的肿胀更有效，表明其作用机制是由于对H1受体的抑制。

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