West Brett J, Deng Shixin, Palu Afa K, Jensen C Jarakae
Research and Development, Tahitian Noni International, American Fork, UT 84003, USA.
J Nat Med. 2009 Jul;63(3):351-4. doi: 10.1007/s11418-009-0327-7. Epub 2009 Mar 13.
Morinda citrifolia Linn. (Rubiaceae) leaves have been used in tropical folk medicine to treat topical inflammation and burns. A carbomer gel base, containing the ethanol extract and juice pressed from the leaves, was evaluated for potential allergenic properties in a repeat-insult patch test in 49 volunteers. To investigate the topical photo-protective properties, the combined ethanol extract and leaf juice were evaluated in a UVB-induced erythema model in 25 volunteers. The crude ethanol extract of M. citrifolia leaves was also evaluated in vitro for potential anti-inflammatory activity in a histamine H-1 receptor antagonism assay. There was no evidence of allergenic potential in the repeat-insult patch test. When the combination of ethanol extract and leaf juice was applied, the UVB dose required to induce erythema was almost 3.5 times greater than with untreated skin (P < 0.001). In the histamine H-1 receptor-binding assay, the crude ethanol extract of M. citrifolia leaves inhibited receptor binding by 57%. These results suggest that M. citrifolia leaves are safe for topical use and may be useful in mitigating UVB-induced injury to the skin.
巴戟天（茜草科）叶在热带民间医学中用于治疗局部炎症和烧伤。在49名志愿者身上进行的重复刺激斑贴试验中，对含有该叶乙醇提取物和压榨汁的卡波姆凝胶基质的潜在致敏特性进行了评估。为了研究局部光保护特性，在25名志愿者的UVB诱导红斑模型中对乙醇提取物和叶汁的组合进行了评估。还在体外组胺H-1受体拮抗试验中对巴戟天叶的粗乙醇提取物的潜在抗炎活性进行了评估。在重复刺激斑贴试验中没有潜在致敏性的证据。当应用乙醇提取物和叶汁的组合时，诱导红斑所需的UVB剂量几乎是未处理皮肤的3.5倍（P<0.001）。在组胺H-1受体结合试验中，巴戟天叶的粗乙醇提取物使受体结合抑制了57%。这些结果表明，巴戟天叶局部使用安全，可能有助于减轻UVB对皮肤的损伤。
