Saporta L, Yuksel A
Department of Urology, Sisli Etfal Teaching (Children) Hospital, Istanbul, Turkey.
Br J Urol. 1994 Aug;74(2):221-4. doi: 10.1111/j.1464-410x.1994.tb16590.x.
To assess the incidence of testicular atrophy by evaluation of hormonal status, testicular histology and sperm production in chronic lepromatous patients.
Forty-one male patients with a mean age of 39.5 years (range 16-57) were studied at the Leprosy Hospital, Istanbul, Turkey, and were compared with 15 age-matched controls with proven fertility.
Reduced testicular size was observed in 51% and gynaecomastia in 27%. Of the 31 patients who were married, 15 were primarily or secondarily infertile. Twelve of 16 patients had oligospermia or azoospermia. The mean basal luteinizing hormone (LH), follicle stimulating hormone (FSH) and oestradiol levels were significantly elevated and the level of testosterone significantly reduced when compared with the control group.
Whenever leprosy is diagnosed patients should be informed of the need for treatment of an acute attack and the need for routine assessment of FSH, LH, testosterone and oestradiol levels to detect hypogonadism and potential infertility.
通过评估慢性瘤型麻风患者的激素状态、睾丸组织学和精子生成情况，来评估睾丸萎缩的发生率。
在土耳其伊斯坦布尔的麻风病医院对41名平均年龄为39.5岁（范围16 - 57岁）的男性患者进行了研究，并与15名已证实有生育能力的年龄匹配的对照组进行了比较。
51%的患者观察到睾丸体积减小，27%的患者出现男性乳房发育。在31名已婚患者中，15名原发性或继发性不育。16名患者中有12名少精子症或无精子症。与对照组相比，基础促黄体生成素（LH）、促卵泡生成素（FSH）和雌二醇水平显著升高，睾酮水平显著降低。
一旦诊断出麻风病，就应告知患者急性发作时需要治疗，以及需要常规评估FSH、LH、睾酮和雌二醇水平，以检测性腺功能减退和潜在的不育症。
