Rao P H, Sreekantaiah C, Schantz S P, Chaganti R S
Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021.
Cancer Genet Cytogenet. 1994 Oct;77(1):60-4. doi: 10.1016/0165-4608(94)90150-3.
We report clonal chromosomal abnormalities in short-term cultures of 11 squamous cell carcinomas of the head and neck. Recurrent deletions were seen at 1p13 (four cases), 6q15q26 (three cases), 6q21q25 (two cases), 12p11.2 (three cases), and 3p13-p23 (three cases). Structural aberrations affecting chromosome 11 with different breakpoints were seen in 7 of 11 tumors. Cytogenetic evidence for gene amplification in the form of homogeneously staining region (hsr) was seen in three tumors (two at 11q13). The results of this study shows that the 1p13, 3p13-p23, 6q15-q26, 6q21-q25, and 12p11.2 were frequently deleted in squamous cell carcinomas of the head and neck.
我们报告了11例头颈部鳞状细胞癌短期培养中的克隆性染色体异常。在1p13（4例）、6q15q26（3例）、6q21q25（2例）、12p11.2（3例）和3p13-p23（3例）发现了反复出现的缺失。11例肿瘤中有7例出现了影响11号染色体且具有不同断点的结构畸变。在3例肿瘤（2例位于11q13）中发现了以均匀染色区（hsr）形式存在的基因扩增的细胞遗传学证据。本研究结果表明，1p13、3p13-p23、6q15-q26、6q21-q25和12p11.2在头颈部鳞状细胞癌中经常发生缺失。
