Yin J C, Wallach J S, Del Vecchio M, Wilder E L, Zhou H, Quinn W G, Tully T
Cold Spring Harbor Laboratory, New York 11724.
Cell. 1994 Oct 7;79(1):49-58. doi: 10.1016/0092-8674(94)90399-9.
Consolidated memory after olfactory learning in Drosophila consists of two components, a cycloheximide-sensitive, long-term memory (LTM) and a cycloheximide-insensitive, anesthesia-resistant memory (ARM). Using an inducible transgene that expresses a dominant negative member of the fly CREB family, LTM was specifically and completely blocked only after induction, while ARM and learning were unaffected. These results suggest that LTM formation requires de novo gene expression probably mediated by CREB family genes.
果蝇嗅觉学习后的巩固记忆由两个部分组成，一个是对放线菌酮敏感的长期记忆（LTM），另一个是对放线菌酮不敏感的抗麻醉记忆（ARM）。利用一个可诱导的转基因来表达果蝇CREB家族的一个显性负性成员，仅在诱导后LTM被特异性地完全阻断，而ARM和学习不受影响。这些结果表明，LTM的形成需要可能由CREB家族基因介导的从头基因表达。
