Tully T, Preat T, Boynton S C, Del Vecchio M
Cold Spring Harbor Laboratory, New York 11724.
Cell. 1994 Oct 7;79(1):35-47. doi: 10.1016/0092-8674(94)90398-0.
Behavioral and pharmacological experiments in many animal species have suggested that memory is consolidated from an initial, disruptable form into a long-lasting, stable form within a few hours after training. We combined these traditional approaches with genetic analyses in Drosophila to show that consolidated memory of conditioned (learned) odor avoidance 1 day after extended training consisted of two genetically distinct, functionally independent memory components: anesthesia-resistant memory (ARM) and long-term memory (LTM). ARM decayed away within 4 days, was resistant to hypothermic disruption, was insensitive to the protein synthesis inhibitor cycloheximide (CXM), and was disrupted by the radish single-gene mutation. LTM showed no appreciable decay over 7 days, was sensitive to CXM, and was not disrupted by the radish mutation.
在许多动物物种中进行的行为和药理学实验表明，记忆在训练后的几个小时内会从最初的、可被破坏的形式巩固为持久的、稳定的形式。我们将这些传统方法与果蝇的基因分析相结合，以表明延长训练1天后，条件性（习得的）气味回避的巩固记忆由两个基因上不同、功能上独立的记忆成分组成：抗麻醉记忆（ARM）和长期记忆（LTM）。ARM在4天内衰退，对低温破坏有抗性，对蛋白质合成抑制剂环己酰亚胺（CXM）不敏感，并被萝卜单基因突变破坏。LTM在7天内没有明显衰退，对CXM敏感，并且不被萝卜突变破坏。
