Kamath P S, Badakere S S, Mehta B C
Blood Bank KEM Hospital, Poona.
Ceylon Med J. 1994 Jun;39(2):97-100.
To determine if anti-idiotype antibodies and circulating immune complexes in individuals before and after immunisation with tetanus toxoid play a role in the immune response.
A study of individuals who were administered a single dose of tetanus toxoid (TT) and who were unimmunized.
Out patient departments of a large public hospital in Bombay, India.
Thirty eight individuals pre-immunisation and forty five individuals post-immunisation with tetanus toxoid, tested at 1, 3, 6, and 12 months.
Development of anti-tetanus anti-idiotype antibodies and circulating immune complexes.
Pre-immunisation cases did show presence of anti-tetanus antibodies but in lower titres than post-immunisation up to six months, after which there was a reduction. Specific anti-idiotype antibodies were detected in 19 cases. One and three months after immunisation more cases had high titre antibodies and circulating immune complexes, though after six months, there was a fall in anti-tetanus antibody titres. Circulating immune complexes were seen in those samples having anti-idiotype antibodies.
Though a significant rise in anti-tetanus antibody anti-idiotype antibodies, protective levels in mice and circulating immune complexes are seen after immunisation with TT it lasts for six months. When followed up for a period of one year it is observed that in cases having auto anti-idiotype antibodies, the anti-tetanus antibodies are maintained for a longer period.
确定破伤风类毒素免疫前后个体中的抗独特型抗体和循环免疫复合物是否在免疫反应中发挥作用。
对接受单剂量破伤风类毒素（TT）的个体和未免疫个体进行研究。
印度孟买一家大型公立医院的门诊部。
38名免疫前个体和45名破伤风类毒素免疫后个体，在1、3、6和12个月时进行检测。
抗破伤风抗独特型抗体和循环免疫复合物的产生。
免疫前病例确实显示存在抗破伤风抗体，但滴度低于免疫后长达6个月，之后有所下降。在19例中检测到特异性抗独特型抗体。免疫后1个月和3个月，更多病例具有高滴度抗体和循环免疫复合物，不过6个月后，抗破伤风抗体滴度下降。在具有抗独特型抗体的样本中可见循环免疫复合物。
尽管用TT免疫后抗破伤风抗体、抗独特型抗体、小鼠中的保护水平和循环免疫复合物有显著升高，但持续6个月。随访一年观察到，在具有自身抗独特型抗体的病例中，抗破伤风抗体维持的时间更长。
