Chen Z, Zheng X, Shi H, Xu W
Institute of Acupuncture, China Academy of Traditional Chinese Medicine, Beijing.
Zhen Ci Yan Jiu. 1993;18(3):183-8.
The present study was undertaken to verify further the participation of motor cortex (MCtx) in the somatosensory area II(SII) emanating descending modulation of thalamic intralaminar nuclei (ILN). Neuronal responses in ILN to noxious stimulation of the superficial peroneal nerve were extracellularly recorded in 34 cats. The effects of electrical stimulating SII on nociceptive responses of neurons in ILN before and after lesion of MCtx were observed and compared. It was shown that electrical stimulation of SII obviously inhibited the nociceptive responses in the majority of neurons recorded (11/13) in ILN in the cats with MCtx intact (P < 0.05). After lesion of MCtx the inhibitory effect still remained (n = 10, P < 0.05), but weakened to a certain extent compared with that before lesion. In the animals with the lesion involving MCtx and the underlying subcortical structures electrical stimulating SII facilitated the nociceptive responses of ILN neurons (n = 7, P < 0.05). The results further support the idea that SII emanating descending modulation on ILN is in part fulfilled via MCtx.
本研究旨在进一步验证运动皮层（MCtx）是否参与了躯体感觉区II（SII）对丘脑板内核（ILN）下行调制的过程。在34只猫中，细胞外记录了ILN对腓浅神经有害刺激的神经元反应。观察并比较了在MCtx损伤前后，电刺激SII对ILN中神经元伤害性反应的影响。结果表明，在MCtx完整的猫中，电刺激SII明显抑制了ILN中大多数记录神经元（11/13）的伤害性反应（P < 0.05）。MCtx损伤后，抑制作用仍然存在（n = 10，P < 0.05），但与损伤前相比有一定程度的减弱。在损伤累及MCtx及其下方皮层下结构的动物中，电刺激SII促进了ILN神经元的伤害性反应（n = 7，P < 0.05）。这些结果进一步支持了SII对ILN的下行调制部分是通过MCtx实现的这一观点。
