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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

J Physiol (Paris). 1976 Nov;72(6):757-67.

The electrical activity of beta-cells is characterized by a regular burst pattern. 2. The bursts occur in a potential range which is not dependent on external glucose concentration. However, there is a clear dose-response relationship between spike frequency or plateau duration and the glucose concentration. 3. There is a striking biphasic pattern of the electrical activity in response to a sudden and sustained stimulation with glucose. 4. These findings agree well with corresponding investigations on insulin release and strongly support the view that insulin release and electrical activity are directly correlated. 5. Concerning the mechanism of the electrical activity, there is evidence that an electrogenic pump plays an important role in the regulation of the burst pattern and presumably in the regulation of insulin release.

β细胞的电活动以规则的爆发模式为特征。2. 爆发发生在一个不依赖于外部葡萄糖浓度的电位范围内。然而，在峰频率或平台期持续时间与葡萄糖浓度之间存在明显的剂量反应关系。3. 对葡萄糖进行突然且持续的刺激时，电活动呈现出显著的双相模式。4. 这些发现与关于胰岛素释放的相应研究结果非常吻合，并有力地支持了胰岛素释放与电活动直接相关的观点。5. 关于电活动的机制，有证据表明一种生电泵在爆发模式的调节中起重要作用，大概也在胰岛素释放的调节中起作用。

J Physiol (Paris). 1976 Nov;72(6):757-67.

The electrical activity of beta-cells is characterized by a regular burst pattern. 2. The bursts occur in a potential range which is not dependent on external glucose concentration. However, there is a clear dose-response relationship between spike frequency or plateau duration and the glucose concentration. 3. There is a striking biphasic pattern of the electrical activity in response to a sudden and sustained stimulation with glucose. 4. These findings agree well with corresponding investigations on insulin release and strongly support the view that insulin release and electrical activity are directly correlated. 5. Concerning the mechanism of the electrical activity, there is evidence that an electrogenic pump plays an important role in the regulation of the burst pattern and presumably in the regulation of insulin release.

β细胞的电活动以规则的爆发模式为特征。2. 爆发发生在一个不依赖于外部葡萄糖浓度的电位范围内。然而，在峰频率或平台期持续时间与葡萄糖浓度之间存在明显的剂量反应关系。3. 对葡萄糖进行突然且持续的刺激时，电活动呈现出显著的双相模式。4. 这些发现与关于胰岛素释放的相应研究结果非常吻合，并有力地支持了胰岛素释放与电活动直接相关的观点。5. 关于电活动的机制，有证据表明一种生电泵在爆发模式的调节中起重要作用，大概也在胰岛素释放的调节中起作用。