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从西班牙患者中分离出的脑膜炎奈瑟菌的血清/亚型分型

Sero/subtyping of Neisseria meningitidis isolated from patients in Spain.

作者信息

Vazquez J A, Marcos C, Berron S

机构信息

Servicio de Bacteriología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

出版信息

Epidemiol Infect. 1994 Oct;113(2):267-74. doi: 10.1017/s0950268800051694.

DOI:10.1017/s0950268800051694
PMID:7925665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2271546/
Abstract

To know the types of meningococcal strains in Spain, we serotyped and subtyped 743 Neisseria meningitidis isolates recovered between 1990 and 1992 from patients. A great number of serogroup B, serogroup C and non-groupable meningococci reacted with the serotyping reagents while many serogroup C and non-groupable isolates did not react with the serosubtyping reagents (78.2% and 54.8% respectively); only 8.9% of serogroup B meningococci were non-subtypeable (NST). Distribution of serotypes was similar in serogroup C and in non-groupable strains. Isolates showed great variability in antigenic phenotypes (71 in serogroup B, 20 in serogroup C and 25 in non-groupable meningococci). The most frequent antigenic combinations were 4:P1.15 (39.8%) in serogroup B, 2b:NST (55.8%) in serogroup C and 2b:NST (35.6%) in non-groupable meningococci.

摘要

为了解西班牙脑膜炎球菌菌株的类型，我们对1990年至1992年间从患者身上分离出的743株脑膜炎奈瑟菌进行了血清分型和亚型分型。大量B群、C群脑膜炎球菌和不可分型脑膜炎球菌与血清分型试剂发生反应，而许多C群和不可分型分离株不与血清亚型分型试剂发生反应（分别为78.2%和54.8%）；只有8.9%的B群脑膜炎球菌不可进行亚型分型（NST）。C群和不可分型菌株的血清型分布相似。分离株在抗原表型上表现出很大的变异性（B群71种，C群20种，不可分型脑膜炎球菌25种）。最常见的抗原组合是B群中的4:P1.15（39.8%）、C群中的2b:NST（55.8%）和不可分型脑膜炎球菌中的2b:NST（35.6%）。

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