Yurino M, Kimura H
Department of Anesthesiology and Resuscitology, Asahikawa Medical College, Japan.
Hokkaido Igaku Zasshi. 1994 May;69(3):537-42.
Sevoflurane allows a moderately rapid induction with only slight problems of induction. However, it has not been possible to conduct tests with more than 2.6 minimum alveolar concentration (MAC) of sevoflurane (4.5%) because of the limitations in the performance of the currently available vaporizer. We tested the performance of a new vaporizer and tried it with single breath induction. The new vaporizer could deliver a 4.3 MAC (7.5%) sevoflurane through oxygen of 8 liter/min. Twenty-one unpremedicated volunteers breathed 7.5% sevoflurane in oxygen. The mean time for induction of anesthesia was 48 +/- 16 seconds, reflecting its high concentration and low blood/gas solubility. Although coughing was observed in two subjects, laryngospasm, breath holding, and secretions did not occur during induction by this method. All subjects except one would be willing to undergo similar induction again. This study demonstrate that the new vaporizer can be used to administer 7.5% concentration of sevoflurane and to adequately perform smooth and rapid inhalation induction of anesthesia in young volunteers without premedication.
七氟醚诱导速度适中，诱导时仅有轻微问题。然而，由于现有蒸发器性能的限制，无法使用超过2.6倍最低肺泡浓度（MAC）的七氟醚（4.5%）进行测试。我们测试了一种新型蒸发器的性能，并尝试用单次呼吸诱导法进行试验。新型蒸发器可通过8升/分钟的氧气输送4.3倍MAC（7.5%）的七氟醚。21名未接受术前用药的志愿者吸入了含7.5%七氟醚的氧气。麻醉诱导的平均时间为48±16秒，这反映了其高浓度和低血/气溶解度。虽然有两名受试者出现咳嗽，但用这种方法诱导时未发生喉痉挛、屏气和分泌物增多的情况。除一名受试者外，所有受试者都愿意再次接受类似的诱导。这项研究表明，新型蒸发器可用于给予7.5%浓度的七氟醚，并能在未接受术前用药的年轻志愿者中充分实现平稳、快速的吸入麻醉诱导。
