绵羊隐孢子虫病中的年龄相关抗性：感染模式与体液免疫反应
Age-related resistance in ovine cryptosporidiosis: patterns of infection and humoral immune response.
作者信息
Ortegà-Mora L M, Wright S E
机构信息
Moredun Research Institute, Edinburgh, United Kingdom.
出版信息
Infect Immun. 1994 Nov;62(11):5003-9. doi: 10.1128/iai.62.11.5003-5009.1994.
Abstract
The phenomenon of age-related resistance to infection with Cryptosporidium parvum has been well characterized in rodent models, and its existence has been demonstrated in calves. To determine whether this is a genuine age effect in a fully susceptible animal model or the result of infection with related pathogens inducing a nonspecific immunity, and to examine several parameters associated with severity of clinical diseases, lambs maintained in a parasite-free environment were infected with C. parvum oocysts at increasing ages. A marked decrease in the severity of clinical symptoms was observed as the age at infection increased, though the kinetics of both fecal and serum antibody responses were similar in all age groups, suggesting that mechanisms other than humoral response may play an important role in the development of age-related resistance. This study demonstrates the first experimental evidence for age-related resistance to ovine cryptosporidiosis and examines parameters which may influence the acquisition of resistance to infection.
摘要
在啮齿动物模型中，与年龄相关的对微小隐孢子虫感染的抵抗力现象已得到充分表征，并且在犊牛中也已证实其存在。为了确定这是在完全易感动物模型中的真正年龄效应，还是感染相关病原体诱导非特异性免疫的结果，并检查与临床疾病严重程度相关的几个参数，将在无寄生虫环境中饲养的羔羊在不同年龄时用微小隐孢子虫卵囊进行感染。随着感染年龄的增加，观察到临床症状的严重程度显著降低，尽管所有年龄组的粪便和血清抗体反应动力学相似，这表明除体液反应外的其他机制可能在与年龄相关的抵抗力发展中起重要作用。本研究证明了与年龄相关的对绵羊隐孢子虫病抵抗力的首个实验证据，并检查了可能影响对感染抵抗力获得的参数。
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