给予抗粒细胞单克隆抗体RB6-8C5可防止先前免疫的小鼠对单核细胞增生李斯特菌感染产生获得性抗性。
Administration of antigranulocyte monoclonal antibody RB6-8C5 prevents expression of acquired resistance to Listeria monocytogenes infection in previously immunized mice.
作者信息
Czuprynski C J, Brown J F, Wagner R D, Steinberg H
机构信息
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
出版信息
Infect Immun. 1994 Nov;62(11):5161-3. doi: 10.1128/iai.62.11.5161-5163.1994.
Abstract
Recent studies have established the importance of neutrophils in innate resistance to Listeria monocytogenes infection in mice. The purpose of this study was to determine the importance of neutrophils in acquired resistance to L. monocytogenes infection. Previously immunized mice that were depleted of neutrophils by administration of the antigranulocyte monoclonal antibody RB6-8C5 demonstrated less resistance to L. monocytogenes challenge than did nonimmunized control mice. In contrast, immunized control mice exhibited a heightened resistance to rechallenge, as expected. These results suggest that neutrophils make previously unrecognized contributions to acquired immunity to a facultative intracellular pathogen.
摘要
最近的研究证实了中性粒细胞在小鼠对单核细胞增生李斯特菌感染的天然抵抗力中的重要性。本研究的目的是确定中性粒细胞在对单核细胞增生李斯特菌感染的获得性抵抗力中的重要性。通过给予抗粒细胞单克隆抗体RB6-8C5使中性粒细胞耗竭的先前免疫小鼠，与未免疫的对照小鼠相比，对单核细胞增生李斯特菌攻击的抵抗力更低。相比之下，免疫对照小鼠如预期的那样对再次攻击表现出增强的抵抗力。这些结果表明，中性粒细胞对兼性细胞内病原体的获得性免疫做出了先前未被认识到的贡献。
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Immunity to intracellular bacteria.对细胞内细菌的免疫
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Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice.中性粒细胞参与小鼠对单核细胞增生李斯特菌的急性非特异性抵抗。
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8
Leukocyte-mediated lysis of infected hepatocytes during listeriosis occurs in mice depleted of NK cells or CD4+ CD8+ Thy1.2+ T cells.在单核细胞增多性李斯特菌病期间，白细胞介导的受感染肝细胞裂解发生在自然杀伤细胞或CD4+ CD8+ Thy1.2+ T细胞耗竭的小鼠中。
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Neutrophils are critical for host defense against primary infection with the facultative intracellular bacterium Francisella tularensis in mice and participate in defense against reinfection.中性粒细胞对于小鼠抵御兼性胞内菌土拉弗朗西斯菌的原发性感染至关重要，并参与抵御再次感染。
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