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Strains of Mycobacterium tuberculosis differ in susceptibility to reactive nitrogen intermediates in vitro.

作者信息

O'Brien L, Carmichael J, Lowrie D B, Andrew P W

机构信息

Department of Microbiology and Immunology, University of Leicester, United Kingdom.

出版信息

Infect Immun. 1994 Nov;62(11):5187-90. doi: 10.1128/iai.62.11.5187-5190.1994.

Abstract

The effects on the viability of Mycobacterium tuberculosis strains and one Mycobacterium bovis strain from exposure to sodium nitrite for 24 h, in both neutral and acidic media, were tested. The in vitro resistance of mycobacteria to reactive nitrogen intermediates, generated at an acidic pH, was found to have a significant (P < 0.05) positive correlation to the virulence of strains in guinea pigs.

摘要

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