结核分枝杆菌菌株在体外对活性氮中间体的敏感性存在差异。
Strains of Mycobacterium tuberculosis differ in susceptibility to reactive nitrogen intermediates in vitro.
作者信息
O'Brien L, Carmichael J, Lowrie D B, Andrew P W
机构信息
Department of Microbiology and Immunology, University of Leicester, United Kingdom.
出版信息
Infect Immun. 1994 Nov;62(11):5187-90. doi: 10.1128/iai.62.11.5187-5190.1994.
Abstract
The effects on the viability of Mycobacterium tuberculosis strains and one Mycobacterium bovis strain from exposure to sodium nitrite for 24 h, in both neutral and acidic media, were tested. The in vitro resistance of mycobacteria to reactive nitrogen intermediates, generated at an acidic pH, was found to have a significant (P < 0.05) positive correlation to the virulence of strains in guinea pigs.
摘要
测试了在中性和酸性培养基中，结核分枝杆菌菌株及一株牛分枝杆菌菌株暴露于亚硝酸钠24小时后对其生存能力的影响。发现分枝杆菌在酸性pH值下对活性氮中间体的体外抗性与豚鼠体内菌株的毒力呈显著（P < 0.05）正相关。
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