Agudo A, Barnadas A, Pallares C, Martinez I, Fabregat X, Rosello J, Estape J, Planas J, Gonzalez C A
Institute of Epidemiological and Clinical Research (IREC), Mataró, Spain.
Int J Cancer. 1994 Oct 15;59(2):165-9. doi: 10.1002/ijc.2910590204.
A case-control study on lung cancer and the habit of cigarette smoking was carried out in Barcelona (Spain). Cases were 103 women newly diagnosed with primary lung cancer in 10 hospitals from the study area. Histologic confirmation was given in 101 cases, of which 53 were adenocarcinoma, 19 squamous-cell carcinoma, 9 small-cell carcinoma and 20 other types. Two controls per case were selected, matched by age, residence and hospital. Compared with the never-smokers, the odds ratios (OR), with corresponding 95% confidence intervals (CI), were 1.61 (0.4 to 6.9) for ex-smokers and 3.61 (1.6 to 8.3) for current smokers. The risk of lung cancer showed a good dose-response relationship with duration of the habit, average number of cigarettes smoked daily and cumulative cigarette consumption. The risk of lung cancer increased by 62% for each 10 pack-years. Depth of inhalation also showed a remarkable effect, independently of the intensity of the habit. Although mortality and incidence rates of lung cancer among women in Spain are lower than in other developed countries, the risk of lung cancer is that which would be expected according to the pattern of the smoking habit in Spanish women.
在西班牙巴塞罗那开展了一项关于肺癌与吸烟习惯的病例对照研究。病例为研究区域内10家医院新诊断出原发性肺癌的103名女性。101例得到了组织学确诊，其中53例为腺癌，19例为鳞状细胞癌，9例为小细胞癌，20例为其他类型。每例病例选取两名对照，按年龄、居住地和医院进行匹配。与从不吸烟者相比，既往吸烟者的比值比（OR）及其相应的95%置信区间（CI）为1.61（0.4至6.9），当前吸烟者为3.61（1.6至8.3）。肺癌风险与吸烟习惯的持续时间、每日平均吸烟量和累积吸烟量呈现出良好的剂量反应关系。每10包年，肺癌风险增加62%。吸入深度也显示出显著影响，与吸烟习惯的强度无关。尽管西班牙女性肺癌的死亡率和发病率低于其他发达国家，但根据西班牙女性的吸烟习惯模式，肺癌风险是预期的风险水平。
